更新时间：2023-09-07 09:01
2020年1月31日，中国科学院微生物研究所研究员严景华发了一条朋友圈：
“没有哪次新发突发传染病疫情的科研攻关像这次这么压力巨大！每天汇报进展，每个人工作进度以小时、分钟计。没有除夕、初一，没日没夜做实验。一帮年轻人连班倒，我心疼他们，也感谢他们！”
2023年中国工程院院士增选的有效候选人，中国科协提名
严景华研究员和高福院士团队多次合作，解析了全球上市的第一个PD-1抗体药物nivolumab（Opdivo）及PD-L1抗体药物avelumab (Bavencio)和durvalumab (Imfinzi)的作用机制（Nature Communications 2017、Cell Research 2017和Protein Cell 2018）。
两团队再次合作对团队筛选的多个PD-1单抗结合表位及功能进行了系统评价，同时对中国第一个获批上市的PD-1单抗toripalimab（拓益）的作用机制进行了研究，成果分别发表在iScience和mAbs杂志。
2020年5月，获得第二届全国创新争先奖。
2020年9月8日，被评为全国抗击新冠肺炎疫情先进个人。
2021年10月，入选第二届民革榜样人物推荐人选名单。
结构为基础的新型疫苗及抗体工程改造
研究内容及意义：
代表性论文(*通讯或第一作者)：
1. Wang Q, Ma T, Wu Y, Chen Z, Zeng H, Tong Z, Gao F, Qi J, Zhao Z, Chai Y, Yang H, Wong G, Bi Y, Wu L, Shi R, Yang M, Song J, Jiang H, An Z, Wang J, Yilma TD, Shi Y, Liu WJ, Liang M, Qin C, Gao GF*, Yan J*. Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. Nature Microbiology.2019 Jul;4(7):1231-1241
2. Liu H, Guo L, Zhang J, Zhou Y, Zhou J, Yao J, Wu H, Yao S, Chen B, Chai Y, Qi J, Gao GF, Tan S, Feng H, Yan J. Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. MAbs. 2019 May/Jun;11(4):681-690.
3. Tan S, Zhang H, Chai Y, Song H, Tong Z, Wang Q, Qi J, Wong G, Zhu X, Liu WJ, Gao S, Wang Z, Shi Y, Yang F, Gao GF*, Yan J* . An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nature Communications. 2017, 8:14369..
4. Wang Q, Yang H, Liu X, Dai L, Ma T, Qi J, Wong G, Peng R, Liu S, Li J, Li S, Song J, Liu J, He J, Yuan H, Xiong Y, Liao Y, Li J, Yang J, Tong Z, Griffin BD, Bi Y, Liang M, Xu X, Qin C, Cheng G, Zhang X, Wang P, Qiu X, Kobinger G, Shi Y, Yan J *, Gao GF *. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. Science Translational Medicine. 2016, 8(369):369ra179.
5. Li Y, Wan Y, Liu P, Zhao J, Lu G, Qi J, Wang Q, Lu X, Wu Y, Liu W, Zhang B, Yuen KY, Perlman S, Gao GF*, Yan J *. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.Cell Research. 2015 , 25(11):1237-49
6. Lu G, Zhang N, Qi J, Li Y, Chen Z, Zheng C, Gao GF, Yan J *. Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. Journal of Virology. 2014 ,88(23):13678-88.
7. Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 2013, 500(7461): 227-31..
8. Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, Gao F, Bi Y, Zhang Y, Fan Z, Qin C, Sun H, Liu J, Haywood J, Liu W, Gong W, Wang D, Shu Y, Wang Y,Yan J, Gao GF. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science. 2013, 342(6155):243-7.
9. Liu J., Qian X., Chen Z., Xu X., Gao F., Zhang S., Zhang R., Qi J., Gao GF., and Yan J *. Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226. Journal of Immunology. 2012, 188(11):5511-20
10. Zhang N*, Yan J﹡, Lu G*, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nature Communications.. 2011, 2:577.
11. Liu J, Dai L, Qi J, Gao F, Feng Y, Liu W,Yan J*, Gao GF. 2011.Diverse peptide presentation of rhesus macaque MHC class I Mamu-A*02 revealed by two peptide-complex structures and insights into SIV immune escape.Journal of Virology.2011. 85(14):7372-83.
12. Lu G,Qi J, Chen Z, Xu X, Gao F, Lin D, Qian W, Liu H, Jiang H,Yan J*, Gao GF*.Enterovirus 71 and Coxsackievirus A16 3C proteases: binding to Rupintrivir and their substrate, and anti-HFMD drug design.Journal of Virology2011, 85(19):10319-31.