更新时间：2023-02-11 11:07
博士，复旦大学免疫学系，（2002-2006）
硕士，上海医科大学免疫学系，（1991-1994）
学士，上海医科大学临床医学系，（1983-1989）
研究生院副院长，复旦大学，（2012.10-2014.02）
医学学位与研究生教育管理办公室主任，复旦大学，（2011.05-2014.02）
系主任，复旦大学基础医学院免疫学系，（2013.06-今）
中心主任，复旦大学生物治疗研究中心，（2010.11-今）
教授，复旦大学基础医学院免疫学系，（2007.04-今）
访问学者，美国EACRI癌症研究中心，（2003.7- 2004.5）（1997.2-1998.8）
博士后，美国华盛顿大学（西雅图），（1995.11-1997.2）
副理事长，中国免疫学会，（2019-今）
副理事长，上海市免疫学会，（2014-今）
曙光学者，上海市，2004
中华医学奖三等奖（第一完成人），2020
上海医学科技奖一等奖（第一完成人），2019
上海市第31届优秀发明奖（第一完成人），2019
宝钢教育基金会优秀教师奖，2019
钟扬式好老师，2019
上海市教学成果二等奖（第一完成人），2018
复旦大学教学成果一等奖（第一完成人），2017
《医学免疫学》上海市高校精品课程 （负责人），2016
《免疫学》教育部首批英语授课品牌课程（负责人），2013
长期从事肿瘤免疫与免疫生物治疗，炎癌转化的免疫学机制研究，以及B淋巴细胞与免疫调节。在肿瘤放化疗后体内免疫系统重建及机制、TLRs抗肿瘤免疫效应及机制研究、以及肿瘤疫苗和CART设计等方面取得系列发现，研发了快速DC疫苗、第四代CART细胞免疫治疗技术。主持和参与多项国家和省部级项目，包括国家自然科学基金重点项目、面上项目、国家重点研发计划、上海市自然科学重点项目等。在国内外学术刊物上发表论文 251 篇，申请或授权专利10余项。主编规划教材《免疫学与病原生物学》,《医学免疫学》，以及人卫出版社英文教材《Medical Immunology》等。
1.Zhiqiang Wang, Zhou Lu, Shengli lin, Jie Xia, ZiwenZhong, Zhangjuan Xie, Yun Xing, Jingbo Qie, Mengxia Jiao, Yifan Li, Haoyu Wen,Pengyuan Zhao, Dan Zhang, Pinghong Zhou, Jiawen Qian, Feifei Luo, Luman Wang,Hongxiu Yu, Jie Liu, Jie Gu, Ronghua Liu*, Yiwei Chu *. Leucine tRNASynthase-2 Expressing B Cells Contribute to Colorectal Cancer Immunoevasion.Immunity.2022May 27;S1074-7613(22)00188-1. doi: 10.1016/j.immuni.2022.04.017. Online aheadof print.
2. Zhou Lu,Ronghua Liu,Yining Wang,Mengxia Jiao,ZhongchenLi,Zhiqiang Wang,Cheng Huang,Guoming Shi,Aiwu Ke,Luman Wang,Ying Fu,Jie Xia,HaoyuWen,Jian Zhou,Xiaoying Wang,Dan Ye,Jia Fan*,Yiwei Chu*,Jiabin Cai *.Ten-eleven translocation-2 inactivation restrains IL-10-producing regulatory Bcells to enable antitumor immunity in hepatocellular carcinoma.Hepatology.2022 Mar 4；doi: 10.1002/hep.32442.
3. Yuedi Wang , Yiyuan Gao , Congyi Niu , Bo Wang , ShushuZhao , Gils Roex , Jiawen Qian , Jingbo Qie , Lin Chen , Chenhe Yi , SébastienAnguille , Jie Liu* , Feifei Luo* , Yiwei Chu *.Chimeric antigen receptor clusteringvia cysteines enhances T-cell efficacy against tumor. CancerImmunol Immunother. 2022 Apr 19. doi: 10.1007/s00262-022-03195-4.
4.YingFu,ZhimingWang,BaichaoYu,YuliLin,EnyuHuang,RonghuaLiu,ChujunZhao,MingfangLv,WeiXu,HongchunLiu,YongzhongLiu,LumanWang*,YiweiChu*.IntestinalCD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A. frontiersin immunology. 2021 Nov 3;12:697725.
5.Baichao Yu ,Luman Wang* , YiweiChu*. Gut microbiota shape B cell in health anddisease settings. J Leukoc Biol. 2021 Aug;110(2):271-281.
6.Yiyuan Gao , Yuedi Wang , Feifei Luo* , YiweiChu*.Optimization of T Cell Redirecting Strategies: Obtaining Inspirations FromNatural Process of T Cell Activation. Front Immunol. 2021 Apr26;12:664329.
7.Wanwei Zheng, Huan Song, Zhongguang Luo, Hao Wu, LinChen, Yuedi Wang Haoshu Cui, Yufei Zhang, Bangting Wang, Wenshuai Li, Yao Liu,Jun Zhang, Yiwei Chu*, Feifei Luo*, Jie Liu*. Acetylcholine amelioratescolitis by promoting IL-10 secretion of monocytic myeloid-derived suppressorcells through the nAChR/ERK pathway. PNAS. 2021 118(11):e2017762118
8.LumanWang,YingFu,BaichaoYu,XuechaoJiang,HongchunLiu,JunLiu,BingbingZha*, Yiwei Chu*. HSP70, a Novel Regulatory Molecule in B Cell-MediatedSuppression of Autoimmune Diseases.Journal of Molecular Biology.2021 Jan 8;433(1):166634
9.Qian J#, Wang C#, Wang B, Yang J, Wang Y, Luo F, Xu J,Zhao C, Liu R, Chu Y*.The IFN-γ/PD-L1 axis between T cells and tumormicroenvironment: hints for glioma anti-PD-1/PD-L1 therapy. J Neuroinflammation.2018 Oct 17;15(1):290.
10.Qian J, Luo F, Yang J, Liu J, Liu R, Wang L, Wang C,Deng Y, Lu Z, Wang Y, Lu M, Wang JY, Chu Y*.TLR2 Promotes Glioma ImmuneEvasion by Downregulating MHC Class II Molecules in Microglia. CancerImmunol Research. 2018 Oct;6(10):1220-1233.
11.Luo F, Qian J, Yang J, Deng Y, Zheng X, Liu J, Chu Y* (corresponding). Bifunctional αHER2/CD3 RNA-engineered CART-like human T cells specifically eliminate HER2(+) gastric cancer. Cell Research. 2016 Jul;26(7):850-3.
12.Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J,Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H,Qian Y, Liu Z, Chu Y*. MicroRNAs 15A and 16-1 Activate SignalingPathways That Mediate Chemotaxis of Immune Regulatory B cells to ColorectalTumors. Gastroenterology. 2018 Feb;154(3):637-651.
13.LuZ, Liu J, Liu X, Huang E, Yang J, Qian J, Zhang D, Liu R, Chu Y*.MiR-15a/16-1 Suppresses AHR-dependent IL-22 Secretion in CD4+ T cells andContributes to Immune-mediated Organ Injury. Hepatology. 2018Mar;67(3):1027-1040.
14.Luo F, Qian J, Yang J, Deng Y, Zheng X, Liu J, Chu Y*.Bifunctional αHER2/CD3 RNA-engineered CART-like human T cells specificallyeliminate HER2(+) gastric cancer. Cell Research. 2016Jul;26(7):850-3.
15.LiuX,Jiang X, Liu R, Wang L, Qian T, Zheng Y, Deng Y, Huang E, Xu F, Chu Y*.Bcells expressing CD11b effectively inhibit CD4+ T cell responses and ameliorateexperimental autoimmune hepatitis in mice. Hepatology. 2015Nov;62(5):1563-75.
16.L Wang, A Ray, X Jiang, J-y Wang, S Basu, X Liu, T Qian, RHe, BN Dittel and Y Chu *.T regulatory cells and B cells cooperate toform a regulatory loop that maintains gut homeostasis and suppresses dextransulfate sodium-induced colitis .Mucosal Immunology. 2015Nov;8(6):1297-312.
17.RonghuaLiu, Jie Gu, Pei Jiang, Yijie Zheng, Xiaoming Liu, Xuechao Jiang , Enyu Huang, ShudaoXiong,Fengkai Xu, Guangwei Liu, Di Ge, Yiwei Chu*. DNMT1-microRNA126epigenetic circuit contributes to esophageal squamous cell carcinoma growth viaADAM9-EGFR-AKT signaling. Clinical Cancer Research,2015;21(4):854-63.
18.Zhang,Feifei Luo, Yuchan Cai, Nan Liu, Luman Wang, Damo Xu and Chu Yiwei *.TLR1/TLR2 agonist induces tumor regression by reciprocal modulation of effectorand regulatory T cells. Journal of Immunology. 2011, 186(4):1963-9. Faculty of 1000