更新时间：2021-07-30 19:10
吴明轩，河南郑州人，博士研究生，现为西湖大学生命科学学院教师。
2004-2010年就读于上海交通大学生命科学与技术学院基地班，先后获得学士和硕士学位，导师为周虎臣教授和白林泉教授。毕业后赴美就读于普林斯顿大学化学系，师从Dorothea Fiedler教授，于2015年获得博士学位。随后师从Philip A. Cole教授，于2015-2017年在约翰霍普金斯大学医学院以及2017-2019年在哈佛医学院布莱根妇女医院从事博士后工作。将于2019年9月入职西湖大学组建化学生物学课题组。
1.M. Wu, D. Hayward, J. H. Kalin, Y. Song, J. W.R. Schwabe and P. A. Cole. “Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex”eLife,2018, 7:e37231.
2. J. H. Kalin, M. Wu, A. V. Gomez, Y. Song, J. Das, D. Hayward, N. Adejola,M. Wu, I. Panova, H. J. Chung, E. Kim, H. J. Roberts, J. M. Roberts, P. Prusevich, J. R. Jeliazkov, S. S. R. Burman, L. Fairall, C. Milano, A. Eroglu, C. M. Proby, A. T. Dinkova-Kostova, W. W. Hancock, J. J. Gray, J. E. Bradner, S. Valente, A. Mai, N. M. Anders, M. A. Rudek, Y. Hu, B. Ryu, J. W.R. Schwabe, A. Mattevi, R. M. Alani, P. A. Cole. “Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.”Nat. Commun.,2018, 8:53.
3.M. Wu, L. S. Chong, D. H. Perlman, A. C. Resnick, D. Fiedler. “The inositol polyphosphates intersect with protein signaling and metabolic networks via two distinct mechanisms.”Proc. Natl. Acad. Sci. USA,2016,113, E6757.
4.M. Wu, L. S. Chong, S. Capolicchio, H. J. Jessen, A. Resnick, D. Fiedler. “Probing diphosphoinositol polyphosphate function with non-hydrolyzable analogs.”Angew. Chem. Int. Ed.2014, 53,7192-7197.
5.M. Wu, B. E. Dul, A. J. Trevisan, D. Fiedler. “Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers.”Chem. Sci.2013,4, 405-410.
6. C.-X. Liu, Q.-Q. Yin, H.-C. Zhou, Y.-L. Wu, J.-X. Pu, L. Xia, W. Liu, X. Huang, T. Jiang,M.-X. Wu, L.-C. He, Y.-X. Zhao, X.-L. Wang, W.-L. Xiao, H.-Z. Chen, Q. Zhao, A.-W. Zhou, L.-S. Wang, H.-D. Sun, G.-Q. Chen. “Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.”Nat. Chem. Biol.2012,8, 486-493.
7.M. Wu, Q. Meng, M. Ge, L. Bai, H. Zhou. “2,3,6-Trideoxy sugar nucleotides: synthesis and stability.”Tetrahedron Lett.2011,52, 5799-5801.