主讲课程

本科生：有机化学，有机合成设计，天然产物化学。

研究生：立体有机化学，天然有机化学。

研究成果和获得奖励

作为课题负责人和主要工作者，先后承担完成国家自然科学基金“七.五”重大项目和“八.五”重点项目各1项，主持国家自然科学基金项目3项。

荣获教育部自然科学奖二等奖1项（2003），国家教委科技进步奖二等奖（1995），三等奖（1997）各1项，甘肃省科技进步奖二等奖1项（1993）。

主编出版《有机合成化学与路线设计》（清华大学出版社，2002）。《磷与生命化学》（清华大学出版社，第8章，2005）。《现代有机合成试剂》（化学工业出版社，2006）。

在国内外重要学术刊物上发表研究论文90余篇。

美国 New Jersey State Rutgers University 植物系

美国 Ohio State University 化学系

美国 University of South Carolina 化学与生物化学系

兰州大学功能有机分子化学国家重点实验室

国际学术交流

第四届国际杂原子学术大会（口头报告，韩国：汉城，1995.8.4-8.7）。

美国 Rutgers 大学植物系合作研究 （1996.9-1998.3）。

美国 Ohio 州立大学化学系合作研究 （2001.7-2002.7）。

第225届美国化学会年会、顺访（口头报告，美国：新奥尔良；Ohio州立大学，2003.3.22-4.5）。

1. Ji SH,Xiao Q,Ju Y（巨勇），Zhao YF,Synthesis of novel dimeric steroidal nucleoside phosphoramidates,Chemistry Letters,2005,34⑺，944-945.

2. Liu MJ,Wang Z,Ju Y（巨勇），Wong RNS,Wu QY. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology， 2005,55⑴，79-90.

3. Liu MJ,Wang Z,Ju Y（巨勇），Zhou JB,Wang Y,Wong RNS,The Mitotic-Arresting and Apoptosis-Inducing Effects of Diosgenyl Saponins on Human Leukemia Cell Lines. Biological & Pharmaceutical Bulletin. 2004,27 ⑺1059-1065.

4. Li HY,Byeon IJL,Ju Y（巨勇），Tsai MD,Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions,Journal of Molecular Biology,2004,335⑴，371-381.

5. Tan B,Lee MC,Cui M,Liu T,Chen ZZ,Li YM,Ju Y（巨勇），Zhao YF,Chen KX,Jiang HL,A common intermediate for prebiotic synthesis of proteins and nucleosides: a density functional theory (DFT) study on the formation of penta-coordinate phosphorus carboxylic–phosphoric mixed anhydride from N-phosphoryl amino acids,Journal of Molecular Structure (Theochem) 2004,672,51–60.

6. Xiao Q,Sun J,Sun Q,Ju Y（巨勇），Zhao YF,Cui YX,Synthesis of AZT 5’-O-Hydrogen phospholipid and their derivatives,Synthesis-Stuttgart,2003，⑴，107-111.

7. Xiao Q,Ju Y（巨勇），Yang XP,Zhao YF,Electrospray ionization mass spectrometry of AZT H-phosphonates conjugated with steroids,Rapid Communications in Mass Spectrometry,2003,17⒀，1405–1410

8. Wang SF,Ju Y（巨勇），Chen XG,Hu ZD,Separation and determination of coumarins in the root bark of three Citrus plants by micellar electrokinetic capillary chromatography,Planta Medica,2003,69⑸，483-486

9. Xiao Q,Ju Y（巨勇），Zhao YF,A facile approach to phosphonic acid diesters,Heteroatom Chemistry,2003,14⑶，208-210.

10. Qin ZH,Lin CX,Ju Y（巨勇），Zhao YF,Synthesis of serine/alanine conjugated 3’，5’- TpT,Nucleosides,Nucleotides & Nucleic Acids,2003,22⑴，63-69.

11. Xiao Q,Sun J,Ju Y（巨勇），Zhao YF,Cui YX,Facile synthesis of 3β-cholesterol H-phosphonates,Chemistry Letters,2003,32⑹，522-523.

12. Xiao Q,Ju Y（巨勇），Zhao YF,One-pot Synthesis of the H-phosphonate of AZT and diosgenin,Chemical Journal of Chinese Universities,2003,24⑻，1427-1429 (in Chinese).

13. Xiao Q,Ju Y（巨勇），Zhao YF,A convenient route to symmetric phosphate,phosphorothioate and phosphoroselenoate of AZT and D4T,Synthetic Communications,2003,33（23），4157-4162.

14. Xiao Q,Sun J,Ju Y（巨勇），Zhao YF,Cui YX,Facile synthesis of bivalent ligand-based phosphoramidates of AZT,Journal of Chemical Research,2003，⑸，262-263.

15. Xiao Q,Ju Y（巨勇），Zhao YF,Cui YX,Characteristic fragmentation behavior of phosphoamino acid conjugates with 3’-azido-3’ -deoxythymidine by electrospray ionization tandem mass spectrometry,Rapid Communications in Mass Spectrometry,2003,17⒇，2273-2278.

16. Wang SF,Chen XG,Hu ZD,Ju Y（巨勇），Analysis of three effective components in Fructus corni and its preparations by micellar electrokinetic capillary chromatography,Biomedical Chromatography,2003,17⑸，306-311.

17. Wang SF,Wu YQ,Ju Y（巨勇），Chen XG,Zheng WJ,Hu ZD,On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of flavonoids in Epimedium brevicornum Maxim,Journal of Chromatography A,2003,1017 （1-2），27-34.

18. Qin DY,Lee H,Yuan CH,Ju Y（巨勇），Tsai MD,Identification of Potential Binding Sites for the FHA Domain of Human Chk2 by in vitro Binding Studies,Biochemical & Biophysical Research Communications,2003,311 ⑷，803-808.

19. Xiao Q,Sun J,Ju Y（巨勇），Zhao YF,Cui YX,Novel approach to the synthesis of AZT 5’-O-hydrogen phospholipids,Tetrahedron Letters,2002,43（30），5281-5283.

20. Qin ZH,Lin CX,Chen Y,Ju Y（巨勇），Zhao YF,Electrospray ionization mass spectrometry of serine/alanine conjugated 5’-UMP and 3’，5’-dithymidine phosphoramidates,Rapid Communications in Mass Spectrometry,2002,16,1997-2002.

21. Cai J,Liu MJ,Wang Z,Ju Y（巨勇），Apoptosis induced by dioscin in hela cells,Biological Pharmaceutical Bulletin,2002,25⑵，193-196.

22. Ju Y（巨勇），Still CC,Sacalis JN,Li J and Ho CT,Cytotoxic coumarins and lignans from extracts of the northern prickly ash,Phytotherapy Research,2001,15,441-443.

23. Hu JJ,Ju Y（巨勇），Zhao Y F,Stereo effect of the peptide formation reaction of N- (O,O-diisopropyl) phosphoryl serine,Chemical Journal Chinese Universities,2001,22⑶，399-402 (in Chinese).

24. Wang Z,Zhou JB,Ju Y（巨勇），Zhang H,Liu MJ,Li X,Effects of two saponins extracted from the Polygonatum zanlanscianense on the human leukemia (HL-60) cells,Biological Pharmaceutical Bulletin,2001,24⑵，159-162.

25. Ju Y（巨勇），Hu JJ,Zhao YF,Reaction of carbohydrates and pentacoordinate oxaphosphorane and their biomimetic mechanism,Phosphorus,Sulfur,Silicon and other Element,2000,167,93-100.

26. Hu JJ,Ju Y（巨勇），Zhao YF,Novel synthesis of tri- and penta-coordinate phosphorous saccharides,Synthetic Communication,2000,30 （22），4087-4092.

27. Hu JJ,Ju Y（巨勇），Zhao YF,LC-MS analysis of the formed peptides from N- (O,O-diisoprpyl) phosphoryl aspartic acid,Chinese Journal of Chemistry,2000,18⑹，932-935.

28. Hu JJ,Ju Y（巨勇），Zhao YF,Studies on reaction of between N-phosphoryl amino acids and ribotides,Chemical Journal of Chinese Universities,2000,21⑾，1667-1670 (in Chinese).