更新时间:2023-01-11 16:57
张翼,毕业于美国新泽西州医科大学,武汉大学教授。
2000年5月 博士学位,美国新泽西州医科大学(University of Medicine and Dentistry of New Jersey)分子遗传与微生物学系。
1992年7月 学士学位,南开大学生物系。
1992-1993 实习实验员,东北制药总厂,沈阳。
1993-1994 实验员,美国Rutgers大学农业生物技术中心,New Brunswick,New Jersey,USA。
1994-1999 博士研究生,美国新泽西州医科大学分子遗传与微生物学系,Piscataway,New Jersey,USA。
2000.1-6 博士后,美国新泽西州医科大学分子遗传与微生物学系 Piscataway,New Jersey,USA。
2000-2003 副教授,武汉大学生命科学学院生化与分子生物学专业,核酶实验室负责人。
2003.11- 教授,武汉大学生命科学学院生化与分子生物学专业。
2004- 博士生导师。
2001.3- 副系主任,武汉大学生命科学学院生物技术系。
2005.1- 武汉大学生命科学学院职称评定委员会委员。
美国微生物协会、美国RNA协会会员,中国生物化学与分子生物学协会RNA专业委员会委员,湖北省生物化学与分子生物学协会理事,《中国生物化学与分子生物学》编委等。
湖北省第十四届人大代表
分子生物学,72学时,生科院本科生专业必修课,国家理科基地名牌课程,武汉大学精品课程。
核酸结构与生物学:54学时,生科院研究生。
高级分子生物学:54学时,生科院研究生。
核酶与非编码RNA的结构与功能。
代表性论文
1. Yan-Fei Jiang, Mu Xiao, Ping Yin and Yi Zhang*. (2006) Monovalent cations use multiple mechanisms to resolve ribozyme misfolding. RNA 12:561-566. (IF=5.84).
2. Mu Xiao, Tingting Li, Xiaoyan Yuan, Yuan Shang, Fu Wang, Shoudeng Chen and Yi Zhang*. (2005) A peripheral element assembles the compact core structure essential for group I self-splicing. Nucleic Acids Research 33:4602-4611. (IF=7.26).
3. Zhijie Li and Yi Zhang*. (2005) Predicting the secondary structures and tertiary interactions of 211 group I introns in IE subgroup. Nucleic Acids Research 33:2118-2128. (IF=7.26).
4. Libin Zhang, Mu Xiao, Chen Lu and Yi Zhang*. (2005) Fast formation of the P3-P7 pseudoknot: a strategy for efficient folding of the catalytically active ribozyme. RNA 11:58-69. (IF=5.84).
5. Mu Xiao, Michael J. Leibowitz and Yi Zhang*. (2003) Concerted folding of a Candida ribozyme to the catalytically active structure posterior to a rapid RNA compaction. Nucleic Acids Research 31:3901-3908. (IF=7.26,封面论文).
其他论文
1. Han-xing Liu, Jun-jian Zhang, Ping Zheng, Yi Zhang. (2005) Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment. Molecular Brain Research, 139 (1): 169-177. (IF=1.77).
2. Zhiqiang Chen and Yi Zhang*. (2005) Dimethylsulfoxide targets phage RNA polymerases to promote transcription. Biochemical and Biophysical Research Communications 333: 664-670. (IF=2.904).
3. Jiangyu Wu, Jiehua Zhou, Fanqi Qu, Penghui Bao, Yi Zhang, Ling Peng. (2005) Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes. Chemical Communications (Camb). 2005(3):313-315. (IF=3.977).
4. Yuan Shang, Chen Wang, Yi Zhang*. (2005) Inducible expression and splicing of Candida group I ribozyme in E. coli. Wuhan University Journal of Natural Sciences (English Edition) 10:465-471. (EI 收录).
5. Xiaoyan Jiang, Guanhua Du, Yi Zhang*. (2005) High throughput screening antifungal drugs using Candida albicans as a model. Chinese Pharmaceutical Journal 39:919-922.
6. Tai-Yuan Li, Ping Yin, Yu Zhou, Yi Zhang*, Yong-Ping Zhang, Tseh-an Chen. (2004) Characterization of the replicon of a 51-kb native plasmid from the gram-positive bacterium Leifsonia xyli subsp. cynodontis. FEMS Microbiology Letters 236: 33-39. (IF=1.84).
7. Lin Cheng, Tai-Yuan Li, Yi Zhang*. (2004) Rapid preparation of total nucleic acids from E. coli for multi-purpose applications. Journal of Biochemistry and Molecular Biology 37:351-355. (IF=1.53).
8. Yi Zhang, Zhijie Li, D. S. Pilch and M. J. Leibowitz. (2002) Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding. Nucleic Acids Research 30:2961-2971. (IF=7.26).
9. Yi Zhang and M. J. Leibowitz. (2001) Folding of the group I intron ribozyme from the 26S rRNA gene of Candida albicans. Nucleic Acids Research 29:2644-2653. (IF=7.26).
已获批专利
李太元,张翼,陈泽安。(2005)一种广谱性质粒稳定因子PSF-Cxc及其分离方法和应用。专利号ZL01138323.2,国际专利主分类号C12N 15/11。证书号208384。