李太生

更新时间:2023-09-06 18:32

李太生,主任医师,教授,博士生导师。现任北京协和医院感染内科主任,北京协和医院艾滋病诊疗中心主任,清华大学医学院特聘教授,中华医学会感染病学分会候任主任委员兼艾滋病学组组长,中国医学科学院艾滋病中心副主任。

擅长领域

1. 发热待查;

2. 各种感染性疾病的诊治;

3. 免疫抑制人群的诊治。

教育经历

1979年09月-1984年08月 广州中山医学院医疗系本科毕业,获医学学士学位

1987年09月-1990年02月 北京协和医科大学内科学学系研究生毕业,获医学硕士学位

1995年12月-1999年01月 法国高等应用研究院地球与生命科学系,获免疫学博士学位

工作经历

1984年09月-1990年12月 北京协和医院内科住院医师,总住院医师

1990年12月-1993年10月 北京协和医院内科感染内科主治医师

1993年10月-1995年12月 国家教育部公派赴巴黎Pitie-Salpetriere医院感染与热带病学科进修学习

1999年01月-1999年10月 北京协和医院感染内科主治医师

1999年10月-2004年08月 北京协和医院感染内科副主任医师

2002年07月-2010年11月 北京协和医院内科学系副主任,感染内科副主任

2002年07月-2017年12月 北京协和医院内科学系总支书记

2002年08月-至今 北京协和医院艾滋病诊疗中心主任

2004年09月-至今 北京协和医院感染内科主任医师

2005年04月-至今 中国协和医科大学 博士生导师

2010年11月-至今 北京协和医院感染内科主任

2018年04月-2021年03月 清华大学医学院特聘教授

社会任职

中华医学会感染病学分会候任主任委员兼艾滋病学组组长

中国医学科学院艾滋病中心副主任

曾任中华医学会热带病和寄生虫分会主委、感染病学分会副主委

学术杂志审稿人

《Emerging Microbes & Infections》

《Journal of Clinical Virology》

《International Journal of Medical Informatics》

《AIDS Care》

《Journal of Medical Virology》

《Therapeutics and Clinical Risk Management》

《AIDS Research and Human Retroviruses》

《International Journal of STD & AIDS》

《SAGE Open Medicine》

《Global Journal of Anesthesiology》

《BMJ Case Reports》

《中华内科杂志》

《中华传染病杂志》

《AIDS》(中文版)

《Chinese Medical Sciences Journal》

《Clinical Intensive Care and Medicine》

学术著作编委

《艾滋病杂志》中文版主编

《柳叶刀传染病》中文版副主编

《中华内科杂志》副主编

《中华传染病杂志》副主编

《中国性病艾滋病杂志》副主编

获奖情况

北京市卫生系统先进工作者(1989年)

卫生部中青年临床科研论文奖二等奖(1993年)

卫生部医药卫生科技进步三等奖(1996年)

国家教育部优秀留法学生(1998年)

法国优秀外国医师奖(Vctoria Hugo奖)(1999年)

中华医学会医药卫生科技进步二等奖(2002年)

北京市科技进步三等奖(2003年)

北京市首都《五一》劳动奖章获得者(2003年)

全国抗击非典优秀科技工作者(2003年)

全国留学回国人员先进个人代表(2003年)

全国《五一》劳动奖章获得者(2004年)

第八届全国青年科技奖获得者(2004年)

国家级新世纪“百千万人才工程”(2006年)

科技部国家科学技术进步二等奖(2007年)

中华医学会医药卫生科技进步三等奖(2007年)

国务院特殊津贴获得者(2008年)

北京市科技进步二等奖(2009年)

中国医学科学院“群众心目中的优秀党员”(2010年)

卫生部突出贡献中青年专家(2010年)

中国医学科学院“协和学者特聘教授”(2010年)

华夏医学科技奖一等奖(2011年)

中华预防医学会科学技术二等奖(2011年)

北京市科学技术奖二等奖(2011年)

当选首批国家“万人计划”科技创新领军人才(2014年)

教育部科学技术进步奖一等奖(2015年)

中华医学科技奖二等奖(2015年)

法国国家医学科学院“塞维雅”奖(2016年)

第十七届吴阶平-保罗·杨森医学药学奖(2016年)

吴阶平医药创新奖(2018年)

2020年全国先进工作者(2020年)

主要学术成就

1. 1998年在国际上提出艾滋病抗病毒免疫重建理论,并将免疫重建理论与我国抗艾实践相结合,牵头搭建全国艾滋病治疗研究网络。开创并不断优化国产抗病毒药物方案,创建了适宜国情的艾滋病抗病毒及免疫重建模式。

2. 主持制定我国首部《艾滋病诊疗指南》,并向全国发布。近年来又在国内率先提出艾滋病综合诊治的理念并建立综合诊治体系,报道了HIV感染者多系统疾病的发病规律,为改善感染者的长期生存质量提供技术支持。

3. 首建临床细胞免疫表型检测平台并应用于疑难危重感染病的诊治。在2003年SARS疫情期间,于国际上最早报道SARS急性期T细胞计数出现显著降低,为早期识别和疫情防控提供了重要依据。在临床实践中提出的“早期、小量、短程”的激素治疗方案,大幅降低了SARS患者的死亡率及并发症。

科研项目

欧盟:欧盟艾滋病疫苗项目

国家“十五”攻关:中国艾滋病病人的抗病毒治疗研究

卫生部:中国艾滋病病人的抗病毒治疗和免疫重建研究

美国NIH:CIPRA-SARS康复病人的临床和细胞免疫反应

“十一五”国家科技重大专项课题:成年艾滋病患者抗病毒治疗和免疫重建研究

北京市科委:北京市HIV/AIDS感染者的治疗药物浓度监测和耐药性研究

国家自然科学基金:中国HIV-1感染者gag特异性细胞毒性T淋巴细胞应答规律研究

中美NIH:中国艾滋病病毒/乙型肝炎病毒共感染者乙型肝炎病毒感染对含替诺福韦或拉米夫定抗逆转录病毒治疗的反应

973:HIV特异性细胞免疫的靶位及其动力学研究

“十二五”国家科技重大专项课题:成人艾滋病适宜治疗策略研究与应用

卫生部临床重点:中国艾滋病患者抗病毒治疗失败的影响因素与应对策略研究

国家科技支撑计划:人免疫功能评价平台建设及临床应用

中国医学科学院医学与健康科技创新工程项目:艾滋病功能性治愈及免疫重建

“十三五”国家科技重大专项课题:艾滋病综合治疗方案的优化及推广应用研究

第一或通讯作者SCI文章目录

(带*为通讯作者)

1、Luo L,Wang N,Yue Y,Han Y,Lv W,Liu Z,Qiu Z,Lu H,Tang X,Zhang T,Zhao M,He Y,Shenghua H,Wang M,Li Y,Huang S,Li Y,Liu J,Tuofu Z,Routy JP, Li T*. The effects of antiretroviral therapy initiation time on HIV reservoir size in Chinese chronically HIV infected patients:a prospective,multi-site cohort study[J]. BMC Infectious Diseases,2019,19(1).

2、Luo L,Wang H,Fan H,Xie J,Qiu Z,Li T*. The clinical characteristics and the features of immunophenotype of peripheral lymphocytes of adult onset chronic active Epstein-Barr virus disease at a Tertiary Care Hospital in Beijing. MEDICINE,97(9)(2018):e9854.

3、Luo L,Han Y,Song X,Zhu T,Zeng Y,Li T*. CD16-expressing monocytes correlate with arterial stiffness in HIV-infected ART-naive men,HIV CLIN TRIALS,19(2)(2018):39-45.

4、Sang X,Chen Y,Chen W,Xie J,Meng G,Zhong J,Li T*,Lu A*. Celastrol specifically inhibits the activation of NLRP3inflammasome.Sci China Life Sci.61(3)(2018):355-357.

5、Lu W,Feng Y,Jing F,Han Y,Lyu N,Liu F,Li J,Song X,Xie J,Qiu Z,Zhu T,Routy B,Routy JP,Li T*,Zhu B*. Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients,Front Microbiol,9(2018):1451.

6、Guo F,Cheng X,Hsieh E,Du X,Fu Q,Peng W,Li Y,Song X,Routy JP,Li T*. Prospective plasma efavirenz concentration assessment in Chinese HIV-infected adults enrolled in a large multicentre study,HIV MED,19(7)(2018):440-451.

7、Guo F,Hsieh E,Lv W,Han Y,Xie J,Li YL,Song XJ,Li TS*. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease. BMC Infect Dis,17(1)(2017):287.

8、Xie J,Hsieh E,Sun MQ,Wang HL,Lv W,Fan HW,Li TS*. Delays in HIV Diagnosis and Associated Factors among Patients Presenting with AdvancedDisease at A Tertiary Care Hospital in Beijing,China. PLOS ONE. 12(8)(2017):e0182335.

9、Du XL,Kou HJ,Fu Q,Li YL,Zhu Z,Li TS*. Steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected Chinese patients. Expert Rev Clin Pharmacol,10(7)(2017):783-788.

10、Li YJ,Xie J,Wang HL,Han Y,Wang ND,Thio CL,Li TS*.. Elevated pre-treatment IL-18 level is associated with HBeAg seroconversion in HIV-HBV coinfection. Antivir Ther,22(6)(2017):523-527.

11、Yue YS,Wang ND,Han Y,Zhu T,Xie J,Qiu ZF,Song XJ,Li YL,Routy JP,Wang JH,Li TS*. A higher CD4/CD8 ratio correlates with an ultralow cell-associated HIV-1 DNA level in chronically infected patients on antiretroviral therapy: a case control study. BMC Infect Dis,17(1)(2017):771.

12、Wang N,Li Y,Han Y,Xie J,Li T*. HIV sequence diversity during the early phase of infection is associated with HIV DNA reductions during antiretroviral therapy. J Med Virol. 89(6)(2017):982-988.

13、Zhang H,Wang HL*,Zhong DR,Liu Y,Li NN,Zhang W,Xiao Y,Li TS*. Fatal Pulmonary Kaposi Sarcoma in an HIV seronegative AIDS patient. Clin Respir J. 11(6)(2017):1040-1044.

14、Wang ND,Li TS*. Factors Associated with the Size of HIV DNA Reservoir[J]. Chinese Medical Journal,130(2)(2017):224-230.

15、Qin L,Xie J,Qiu ZF,Cao W,Jiao Y,Jean‐Pierre Routy,and Li TS*. Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults . AGING-US,8(5)(2016):848-859.

16、Guo FP,Li YJ,Qiu ZF,Lv W,Han Y,Xie J,Li YL,Song XJ,Du SS,Mehraj V,Li TS*,Routy JP. Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected Late Presenters. Chin Med J (Engl). 129(22)(2016):2683-2690.

17、Xie J,Han Y,Qiu ZF,Li YJ,Li YL,Song XJ,Wang HL,Chloe L Thio,Li TS*. Prevalence of hepatitis B and C viruses in HIV-positive patients in China: a cross-sectional study. J Int AIDS Soc,19:20659(2016).

18、Li YJ,Xie J,Han Y,Wang HL,Zhu T,Wang ND,Lv W,Guo FP,Qiu ZF,Li YL,DuSS,Song XJ,Chloe L Thio,Li TS*.Lamivudine monotherapy-based cART is efficacious for HBV treatment in HIV/HBV co-infection when baseline HBV DNA<20,000IU/ml. J Acquir Immune DeficSyndr. 72(1)(2016): 39-45.

19、Li YJ,Xie J,Han Y,Wang HL,Lv W,Guo FP,Qiu ZF,Li YL,Du SS,Song XJ,Zhu T,Thio,CL,Li TS*. Combination Antiretroviral Therapy Is Associated With Reduction in Liver Fibrosis Scores in HIV-1-Infected Subjects. MEDICINE,95(5)(2016):e2660.

20、Hsieh E,Fraenke L,Han Y,Xia W,Insogna KL,Yin MT,Zhu T,Cheng X,Li TS*. Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV. AIDS. 30(12)(2016):1935-1942.

21、Li HP,Chang S,Han Y,Zhuang D,Li L,Liu Y,Liu S,Bao Z,Zhang W,Song H,Li TS*,Li J*. The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post-2004[J]. BMC infectious diseases,16(605)(2016).

22、Han Y,Li YJ,Xie J,Qiu ZF,Li YL,Song XJ,Zhu T,Li TS*.Week 120 efficacy of tenofovir,lamivudine and lopinavir/r-based second-line antiretroviral therapy in treatment-experienced HIV patients. PLoS One.10(3)(2015)e120705.

23、Dou HT,Xu Y,Li TS*. Application of the DiversiLab system for tracing the source of the mixed infections caused by Cryptococcus neoformans var. grubii from a patient with systemic lupus erythematosus. Mycoses. 58(3)(2015):149-159.

24、Zhang CD,Chow FC,Han Y,Xie J,Qiu Z,Guo F,Li Y,Wang H,Li TS*. Multicenter cohort study of diabetes mellitus and impaired fasting glucose in HIV-infected patients in China. J Acquir Immune DeficSyndr. 68(3)(2015):298-303.

25、GE Y& Li TS*.May early intervention with intravenous immunoglobulin pose a potentially successful treatment for Ebola virus infection? Life Sciences58(1)(2015):108-110.

26、Li YJ,Gu LJ,Han Y,Xie J,Wang HL,Lv W,Song XJ,Li YL,Iwamoto,A,Ishida T,Li TS*. HIV-1 Subtype B/B ' and Baseline Drug Resistance Mutation Are Associated With Virologic Failure: A Multicenter Cohort Study in China. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,68(3)(2015):289-297.

27、Hsieh E,Fraenkel L,Xia W,Hu YY,Han Y,Insogna K,Yin MT,Xie J,Zhu T,Li TS*. Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV. Osteoporos Int.26(3)(2015):1035-1044.

28、Gu LJ,Han Y,Li Y,Zhu T,Song X,Huang Y,Yang F,Guan S,Xie J,Gohda J,Hosoya N,Kawana-Tachikawa A,Liu W,Gao GF,Iwamoto A,Li TS*,Ishida T. Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China. PLoS One. 10(8)(2015) e0134539.

29、Li TS*,Xie J,Li Y,Routy JP,Li Y,Han Y,Qiu Z,Lv W,Song X,Sun M,Zhang X,Wang F,Jiang H. Tripterygium wilfordii Hook F extract in cART-treated HIV patients with poor immune response: a pilot study to assess its immunomodulatory effects and safety. HIV Clin Trials. 16(2)(2015):49-56.

30、Fan HW,Guo FP,Li YJ,Li N,Li TS*. Prevalence of thrombocytopenia among Chinese adult antiretroviral-naïveHIV-positive patients. Chin Med J (Engl). 128(4)(2015):459-464.

31、Li YJ,Han Y,Xie J,Gu L,Li W,Wang H,Lv W,Song X,Li Y,Routy JP,Ishida T,Iwamoto A,Li TS*; CACT0810 group. CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission. AIDS.28(4)(2014):521-530.

32、Guo FP,Liu Y,Li Y,Fan H,Li TS*. Disseminated Mycobacterium avium complex infection manifested as Brown-Séquard syndrome in an HIV-infected patient. Chin Med J (Engl). 127(4)(2014):799.

33、Luo L,Zeng Y,Li TS*,Lv W,Wang HL,Guo FP,Han Y,Xie J,Qiu ZF,Li YL,Song XJ,Zhu T,Zhang XY,Li L,Ye YC,He Y,Lu HZ,Huang AQ,Tang XP,Wang H,Zhang T,Gao GJ,Lei JK,Wu XH,Sun YT,Bai JS,Li KL. . Prospective Echocardiographic Assessment of Cardiac Structure and Function in Chinese Persons Living With HIV. Clinical Infectious Diseases,58(10)(2014):1459-1466.

34、Li TS*,Guo F,Li Y,Zhang C,Han Y,Lye W,He Y,Lu H,Xie J,Huang A,Li Y,Tang X,Wang H,Zhang T,Gao G,Lei J,Zhang X,Wu X,Sun Y,Bai J,Luo L,Wang H. An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-line HIV therapy is optimal in resource-limited settings: a prospective,multicenter study in China. Chin Med J (Engl). 127(1)(2014):59-65.

35、Cao W,QiuZF,Zhu T,Li Y,Han Y,Li TS*.CD8+ T cell responses specific for hepatitis B virus core protein in patients with chronic hepatitis B virus infection. Journal of Clinical Virology.61(2014): 40-46.

36、Hsieh E,Fraenkel L,Bradley EH,Xia W,Insogna KL,Cui Q,Li K,Li TS*.Osteoporosis knowledge,self-efficacy,and health beliefs among Chinese individuals with HIV. Arch Osteoporos. 9(1)(2014):201.

37、Ge Y,Li TS*,Liu ZY,Liu M,Guan H,Chen L,Tian Y,Zhuang Q. A rare cause of fever of unknown origin-cervical spinal cord lesion. Chin Med J (Engl).127(19)(2014):3517-3518.

38、Hsieh E,Fraenkel L,Bradley E,Xia W,Qu C,Ling L,Insogna K,Li TS*. Osteoporosis knowledge,self-efficacy,and health beliefs among chinese men and women with HIV. Ann Rheum Dis. 73 Suppl 1(2014):A62-3.

39、Hsieh E,Fraenkel L,Xia W,Hu Y,Han Y,Insogna K,Yin MT,Xie J,Zhu T,Li TS*.Increased bone turnover after switch to tenofovir + lopinavir/ritonavir in chinese HIV + patients. Ann Rheum Dis. 73 Suppl 1(2014):A62.

40、Kou HJ,Du X,Li Y,Xie J,Qiu Z,Ye M,Fu Q,Han Y,Zhu Z,Li TS*,Comparison of nevirapine plasma concentrations between lead-in and steady-state periods in Chinese HIV-infected patients. PLoS One. 8(1)(2013):e52950.

41、Cao Y,Gong M,Han Y,Xie J,Li X,Zhang L,Li Y,Song X,Zhu T,Li TS*. Prevalence and risk factors for chronic kidney disease among HIV-infected antiretroviral therapy-naïve patients in Chinese mainland:A multicenter cross-sectional study. Nephrology (Carlton). 18(4)(2013):307-312.

42、Zhang C,Wang W,Zhou M,Han H,Xie J,Qiu Z,Guo F,Li Y,Wang H,Ghanem KG,Li TS*. The Interaction of CD4 T-Cell Count and Nevirapine Hepatotoxicity in China: A Change in National Treatment Guidelines May Be Warranted. J Acquir Immune Defic Syndr.62(2013):540–545.

43、Cao Y,Han Y,Xie J,Cui Q,Zhang L,Li Y,Li Y,Song X,Zhu T,Li TS*. Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted Prorese inhibitor-based regimen on renal function in HIV-infected Individuals:a prospective,multicenter study. BMC Infect Dis.13(2013):301.

44、Zhang LX,Su Y,Hsieh E,Xia W,Xie J,Han Y,Cao Y,Li Y,Song X,Zhu T,Li TS*,Yu W. Bone turnover and bone mineral density in HIV-1 infected Chinese taking highly active antiretroviral therapy-a prospective observational study. BMC MusculoskeletDisord. 14(2013):224.

45、Wang HL,Ghanem KG,Wang P,Yang S,Li TS*. Listeriosis at a tertiary care hospital in beijing,china: High prevalence of non-clustered healthcare-associated cases among adult patients. Clin Infect Dis.56(5)(2013):666-676.

46、Kou H,Du X,Li Y,Fu Q,Zhu Z,Li TS*.Quantification of tenofovir in human plasma by solid-phase extraction and high-performance liquid chromatography coupled with UV detection. Ther Drug Monit. 34(5)(2012):593-598.

47、Wang H,Li Y,Zhang C,Han Y,Zhang X,Zhu T,Li TS*. Immunological and virological responses to cART in HIV/HBV co-infected patients from a multicenter cohort. AIDS. 26(14)(2012):1755-1763.

48、Kou HJ,Ye M,Fu Q,Han Y,Du X,Xie J,Zhu Z,Li TS*. Simultaneous quantification of lopinavir and ritonavir in human plasma by high performance liquid chromatography coupled with UV detection. SciChina Life Sci. 55(4)(2012):321-327.

49、Li YJ,Wang HL,Li TS*. Hepatitis B virus/human immunodeficiency virus coinfection: Interaction among human immunodeficiency virus infection,chronic hepatitis B virus infection,and host immunity. Chin Med J (Engl). 125(13)(2012):2371-2377.

50、Li,CG; Yang,PH; Sun,Y; Li,TS; Wang,C; Wang,Z; Zou,Z; Yan,YW; Wang,W; Wang,C; Chen,ZW; Xing,L; Tang,C; Ju,XW; Guo,F; Deng,JJ; Zhao,Y; Yang,P; Tang,J; Wang,HL; Zhao,ZP; Yin,ZN; Cao,B; Wang,XL; Jiang,CY. 2012. IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus. CELL RESEARCH,22(3):528-538.

51、Liu LF,Wang L,Fu Q,Zhu Z,Xie J,Han Y,Liu ZY,Ye M,Li TS*. Steady-state pharmacokinetics of zidovudine in ChineseHIV-infected patients. Chin Med J (Engl). 125(11)(2012):1931-1935.

52、Li TS*,Wu N.CD31(+) Cell Percentage Correlation With Speed of CD4(+) T-Cell Count Recovery in HIV-Infected Adults Is Reversed in Children:Higher Thymic Output May Be Responsible Reply. CLIN INFECT DIS .55(2) (2012):307-309.

53、Cao W,Qiu ZF,Li TS*. Parallel decline of CD8+CD38+ lymphocytes and viremia in treated hepatitis B patients. World J Gastroenterol. 17(17)(2011):2191-2198.

54、Liu LF,Xie J,Sun J,Han Y,Zhang C,Fan H,Liu Z,Qiu Z,He Y,Li TS*. Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients[J]. Scandinavian journal of infectious diseases,43(6-7)(2011):515-521.

55、Li TS*,Wu N,Dai Y,Qiu Z,Han Y,Xie J,Zhu T,Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis. 53(9)(2011):944-51.

56、Han Y,Wu N,Zhu WJ,Li YL,Zuo LY,Ye JJ,Qiu ZF,Xie J and Li TS*.Detection of HIV-1 viruses in tears of patients evenunder long-term HAART,AIDS,25(15)(2011):1925-1927.

57、Wang J,Kou H,Fu Q,Han Y,Qiu Z,Zuo L,Li Y,Zhu Z,Ye M,Ma Q,Li TS*.Nevirapine plasma concentrations are associated with virologic response and hepatotoxicity in Chinese patients with HIV infection. PLoS One. 6(10)(2011):e26739.

58、Luo L,Li TS*.Overviewof antiretroviral treatment in china:advancement and challenges Chinese Medical Journal;124(3)(2011):440-444.

59、Ye M,Wang L,Fu Q,Zhu Z,Li P,Li TS*. Steady-State Pharmacokinetics of Lamivudine Once-Daily Versus Twice-Daily Dosing in Chinese HIV-Infected Patients. HIV Clin Trials. 11(4)(2010):230-237.

60、Ye Y,Zeng Y,Li X,Zhang S,Fang Q,Luo L,Qiu Z,Han Y,Li TS*. Human immunodeficiency Virus Infection: An Independent Risk Factor of Peripheral Arterial Disease. J Acquir Immune DeficSyndr. 53(2)(2010):276-278.

61、Guo FP,Lv W,Han Y,Qiu ZF,Zuo LY,Li YL,Li TS*. Impact of Hepatitis C Virus Coinfection on HAART in HIV-Infected Individuals: Multicentric Observation Cohort. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,54(2)(2010):137-142.

62、Luo L,Ye Y,Guo F,Zuo L,Li Y,Qiu Z,Han Y,Li L,Zeng Y*,Li TS*. Assessment of cardiac diastolic dysfunction in HIV-infected people without cardiovascular symptoms in China. Int J STD AIDS;21(12)(2010):814-818.

63、Zeng Y,Ye Yc,Luo L,Qiu ZF,Han Y,Li XM,Fang QA,Zang SY and Li TS*.Premature atherosclerosis in patients with acquired immunodeficiency syndrome. Chinese Medical Journal,123(23)(2010):3396-3399.

64、Cao ZL,Liu LF,Du LY,Zhang C,Jiang S,Li TS*,He YX*. Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients[J]. Virology journal,7(2010):299.

65、Xie J,Jiao Y,Qiu Z,Li Q,Li TS*. Significant elevation of B cells at acute stage in enterovirus 71-infected children with central nervous system involvement. Scand J Infect Dis. 42(11-12)(2010):931-935.

66、Liu J,Wu P,Gao F,Qi JX,Kawana-Tachikawa,A,Xie J,Vavricka,CJ, Iwamoto,A,Li TS*,Gao GF. Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain Hydrogen Bonds from Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein. JOURNAL OF VIROLOGY. 84(22)(2010):11849-11857.

67、Jiao Y,Qiu ZF,Xie J,Li DJ,Li TS*. Reference ranges and age-related changes of peripheral blood lymphocyte subsets in Chinese healthy adults. Sci China C Life Sci,52(7)(2009):643-650.

68、Liu ZY,Guo FP,Han Y,Qiu ZF,Zuo LY,Li YL,Li TS*. Impact of baseline CD4(+) T cell counts on the efficacy of nevirapine-based highly active antiretroviral therapy in Chinese HIV/AIDS patients: a prospective,multicentric study. Chin Med J (Engl). 122(20)(2009):2497-2502.

69、Luo L,Zhang L,Tao MM,Qiu ZF,Xie J,Han Y,Li M,Li TS*. Adiponectin and Leptin Levels in Chinese Patients with HIV-Related Lipodystrophy: A 30-Month Prospective Study. AIDS Res Hum Retroviruses. 25(12)(2009):1265-1272.

70、Zhang HW,Qiu ZF,Jiao Y,Wang AX,Li TS*. HIV-specific CD8(+) T cell responses to HXB2 Gag and Nef peptide pools in Chinese HIV/AIDS patients. SCIENCE IN CHINA SERIES C-LIFE SCIENCES. 52(9)(2009):841-846.

71、Luo L,Li TS*.Idiopathic CD4 Lymphocytopenia and opportunistic infection an update.FEMSImmunol Med Microbiol.54(2008):283-289.

72、Li TS*,Dai Y,Kuang JQ,Jiang JM,Han Y,Qiu ZF,Xie J,Zu,LY,Li YL. Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese HIV/AIDS Patients: Multicentric Observation Cohort. PLOS ONE. 3(12)(2008):e3918.

73、Qing ML,Li TS*,Han Y,Qiu ZF,Jiao Y. Accelerating effect of human leukocyte antigen-Bw6 homozygosity on disease progression in Chinese HIV-1 - Infected patients. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 41(2)(2006):137-139.

74、Jiao Y, Xie J,Li TS*,Han Y,Qiu ZF,Zuo LY,Wang AX. Correlation between Gag-specific CD8 T-cell responses,viral load and CD4 count in HIV-1 infection is dependent on disease status. J Acquir Immune DeficSyndr,42(3)(2006):263-268.

75、Jiao Y,Li TS*,Xie J,Han Y,Qiu ZF,Zuo LY,Thomas Mourez,Wang AX. Association between Nef-Specific CD8+ T-Cell Responses and disease progression in HIV-1 Subtype B Infection. Chinese Medical Journal,119(19)(2006):1609-1615.

76、Wang AX,Wang FS,Wang QY,Jian W,Feng TJ,Lu HZ,Sun HQ,Sun YT,Ye HH,Li TS*,Li XW,Liu ZY,Xing YL,Yun H,Ning W,Hao W,Wu NP,Zhang FJ,Zhou ZQ,Gong EC,Zhao HX,Min Z,Tang XP,Xu LZ,Xu XY,Cao YZ,Kang LY,Yan J,Cai WP,Fan QB,Pan XZ. Guidelines for diagnosis and treatment of HIV/AIDS in China (2005). CHINESE MEDICAL JOURNAL. 119(19)(2006): 1589-1608.

77、Dai Y,QiuZF,Li TS*,Han Y,Zuo LY,Xie J,Ma XJ,Liu ZY,Wang AX. Clinical outcomes and immune reconstitution in 103 advanced AIDS patients undergoing 12-month highly active antiretroviral therapy. Chinese Medical Journal,119(20)(2006):1677-1682.

78、Li TS*,Xie J,He Y,Fan H,Baril L,Qiu Z,Han Y,Xu W,Zhang W,You H,Zuo Y,Fang Q,Yu J,Chen Z,Zhang L. Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus[J]. PloS one,1(2006):e241.

79、Li TS*,Qiu ZF,Zhang LQ,Han Y,He W,Liu ZY,Ma XJ,Fan HW,Lu W,Xie J,Wang HL,Deng GH,Wang A. Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome. JOURNAL OF INFECTIOUS DISEASES. 189(4)(2004):648-651.

80、LI TS*,Qiu ZF,Han Y,Wang Z,Fan HW,Lu W,Xie J,Ma XJ and Wang AX. Rapid loss of both CD4~+ and CD8~+ T lymphocyte subsets during the acute phase of severe acute respiratory syndrome[J]. Chinese medicaljournal,116(7)(2003):985-987.

81、Li TS; Tubiana R; Fillet AM; Autran B; Katlama,C. Negative result of cytomegalovirus blood culture with restoration of CD4(+) T-cell reactivity to cytomegalovirus after HAART in an HIV-1-infected patient.JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES.20(5)(1999):514-515.

82、Gorochov,G; Neumann,AU; Kereveur,A; Parizot,C; Li,TS; Katlama,C; Karmochkine,M; Raguin,G; Autran,B; Debre,P. 1998. Perturbation of CD4(+) and CD8(+) T-cell repertoires during progression to AIDS and regulation of the CD4(+) repertoire during antiviral therapy. NATURE MEDICINE. 4(2):215-221.

83、Li TS;Tubiana,R; Katlama,C; Calvez,V; AitMohand,H; Autran,B. Long-lasting recovery in CD4+ T cell function minors viral load reduction after highly active anti-retroviral therapy in patients with advanced HIV disease. Lancet. 351(1998):1682-1686.

84、Autran,B; Carcelain,G; Li,TS; Blanc,C; Mathez,D; Tubiana,R; Katlama,C; Debre,P; Leibowitch,J. 1997. Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease. SCIENCE.277(5322):112-116.

著作译作

1. 李太生共同主编,《国家卫生和计划生育住院医师规范化教材内科学感染科分册》,人民卫生出版社出版,2016年,北京。

2. 李太生主编,《中华医学百科全书》感染性疾病学卷,中国协和医科大学出版社,2013年,北京。

3. 李太生,艾滋病的免疫应答和免疫重建研究进展,第496-511页,《中国艾滋病流行与控制》,王陇德主编,北京出版社,2006,北京。

4. 李太生,艾滋病,第175-191页,肺孢子菌病,不明原因发热的诊断思维,418-421页,558-563页,免疫缺陷患者的感染,586-599页,《感染病学》,李兰娟等主编,人民卫生出版社,2005,北京。

科普宣传

曾在《养生堂》、《职场健康课》、《人民网》等进行科普宣传。

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