王韵华

更新时间:2023-07-05 12:52

王韵华,女,汉族,1988-1997年复旦大学化学系讲师,1997年晋升为复旦大学化学系副教授,2006年4月起任教授

主讲课程

主讲《普通化学》以及《化学综合实验》等课程,主要从事生物无机化学领域基础理论研究工作。

研究方向

顺铂类无机抗癌药物研究,金属蛋白性质、结构、功能间关系研究。

主要贡献

(1) Effects of charged amino acid mutation on the solution structure of cytochrome b5 and binding between cytochrome b5 and cytochrome c. Protein Science (2001) 10 2451-2459.

(2) Engineering a hydrophilic heme catalytic pocket into microsomal cytochrome b5: construction of novel metalloproteins with high peroxidase-like activity. Chemistry Lett. (2002) 7 674-675.

(3) Crystal structures of V45E and V45Y mutants and structure comparison of a variety of mutants of cytochrome b5. Acta Crystallography (2002) D58 1298-1306.

(4) The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5. Protein Engineering (2003) 16 1-8.

(5) Mapping the electron transfer interface between cytochrome b5 and cytochrome c. Biochemistry (2004) 43 3527-3536.

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