更新时间:2023-07-05 12:52
主讲《普通化学》以及《化学综合实验》等课程,主要从事生物无机化学领域基础理论研究工作。
顺铂类无机抗癌药物研究,金属蛋白性质、结构、功能间关系研究。
(1) Effects of charged amino acid mutation on the solution structure of cytochrome b5 and binding between cytochrome b5 and cytochrome c. Protein Science (2001) 10 2451-2459.
(2) Engineering a hydrophilic heme catalytic pocket into microsomal cytochrome b5: construction of novel metalloproteins with high peroxidase-like activity. Chemistry Lett. (2002) 7 674-675.
(3) Crystal structures of V45E and V45Y mutants and structure comparison of a variety of mutants of cytochrome b5. Acta Crystallography (2002) D58 1298-1306.
(4) The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5. Protein Engineering (2003) 16 1-8.
(5) Mapping the electron transfer interface between cytochrome b5 and cytochrome c. Biochemistry (2004) 43 3527-3536.