更新时间：2024-08-16 10:54
裴伟士，1949年11月10日出生于斯里兰卡，临床及公共卫生病毒学家，香港科学院创院院士，美国国家科学院外籍院士，香港大学李嘉诚医学院病毒学讲座教授、公共卫生学院院长、谭华正基金（医疗科学）教授。
1949年11月10日，裴伟士出生于斯里兰卡。
1972年，从锡兰大学（现科伦坡大学）医科毕业，获得医学学士学位。
1981年，从英国牛津大学毕业，获得病毒学博士学位，之后在纽卡斯尔皇家维多利亚医院接受临床病毒学训练。
1995年，进入香港大学工作。
2006年，当选为伦敦皇家学会会士；同年，被美国《时代杂志》评选为过去六十年为亚洲控制传染学作出贡献，六十三位的亚洲英雄其中一位杰出人物。
2015年，当选为香港科学院创院院士。
2017年，当选为美国国家科学院外籍院士。
裴伟士的研究涵盖了人类和动物流感病毒的发病机制、先天免疫反应、传播模式、生态学和流行病学，如H5N1 、H9N2和H7N9甲型禽流感、2009年的人类猪流感病毒，以及引发「沙士」的冠状病毒（SARS-CoV-1 ）、中东呼吸综合症冠状病毒（MERS-CoV ）和新型冠状病毒（SARS-CoV-2 ）等。
裴伟士领导的研究团队于2003年发现新型冠状病毒为引致非典型肺炎的病原体，此重大发现对该疾病的诊断、病理和控制方面起关键作用；他也从事关于对抗动物流感病毒病的工作。他曾代表世界卫生组织，调查在沙特阿拉伯爆发的中东呼吸综合征及到中国研究H7N9禽流感。除此之外，他带领团队研究新型冠状病毒所引致的2019冠状病毒流行病（COVID-19 pandemic）。
根据2022年6月香港大学公共卫生学院网站显示，裴伟士先后在国际科学期刊上发表逾800篇同行评审的研究，文章被引用超过76,000次，代表论文如下：
Peiris JSM, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY. Coronavirus as a possible cause of severe acute respiratory syndrome[J]. Lancet. 2003; 361:1319-25.
Peiris JSM, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, Law KI, Tang BSF, Hon TYW, Chan CS, Chan KH, Ng JSC, Zheng BJ, Ng WL, Lai RWM, Guan Y, Yuen KY. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study[J]. Lancet. 2003; 361: 1767-72.
Cheung CY, Poon LL, Lau AS, Luk W, Lau YL, Shortridge KF, Gordon S, Guan Y, Peiris JSM. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?[J] Lancet. 2002; 360:1831-7.
Li KS, Guan Y, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie AT, Chaisingh A, Auewarakul P, Long HT, Hanh NT, Webby RJ, Poon LL, Chen H, Shortridge KF, Yuen, KY, Webster RG, Peiris JSM. Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia[J]. Nature. 2004; 430: 209-13.
Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JSM. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo[J]. Proc Natl Acad Sci U S A. 2016; 113:3621-6.
Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, Yu J, Kang M, Song Y, Xia J, Guo Q, Song T, He J, Yen HL, Peiris M, Wu J. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients[J]. N Engl J Med. 2020; 382:1177-1179.
Chu DKW, …Peiris M, Poon LLM. Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia[J]. Clin Chem. 2020; 66: 549-555.
Sit THC, Brackman CJ, Ip SM, Tam KWS, Law PYT, To EMW, Yu VYT, Sims LD, Tsang DNC, Chu DKW, Perera RAPM, Poon LLM, Peiris M. Infection of dogs with SARS-CoV-2[J]. Nature. 2020; 586:776-778.
Sia SF, Yan LM, Chin AWH, Fung K, Choy KT, Wong AYL, Kaewpreedee P, Perera RAPM, Poon LLM, Nicholls JM, Peiris M, Yen HL. Pathogenesis and transmission of SARS-CoV-2 in golden hamsters[J]. Nature. 2020;583:834-838.
Lau EHY, Tsang OTY, Hui DSC, Kwan MYW, Chan WH, Chiu SS, Ko RLW, Chan KH, Cheng SMS, Perera RAPM, Cowling BJ, Poon LLM, Peiris M. Neutralizing antibody titres in SARS-CoV-2 infections[J]. Nat Commun. 2021;12:63.
Leung NHL, Chu DKW, Shiu EYC, Chan KH, McDevitt JJ, Hau BJP, Yen HL, Li Y, Ip DKM, Peiris JSM, Seto WH, Leung GM, Milton DK, Cowling BJ. Respiratory virus shedding in exhaled breath and efficacy of face masks[J]. Nat Med. 2020;26:676-680.
Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG, Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M*. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity[J]. Proc Natl Acad Sci U S A. 2018; 115: 3144-3149.
Chan RW, Hemida MG, Kayali G, Chu DK, Poon LL, Alnaeem A, Ali MA, Tao KP, Ng HY, Chan MC, Guan Y, Nicholls JM, Peiris JSM*. Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study[J]. Lancet Respir Med. 2014; 2:813-22.
Vijaykrishna D, Smith GDJ, Pybus OG, Zhu H, Bhatt S, Poon LLM, Riley S, Bahl J, Ma SK, Cheung CL, Perera RAPM, Chen H, Shortridge KF, Webby RJ, Webster RG, Guan Y*, Peiris JSM*. Long-term evolution and transmission dynamics of swine influenza A virus[J]. Nature 2011; 473: 519-22.
Cowling BJ, Chan KH, Fang VJ, Lau LLH, So THC, Fung ROP Ma ESK, Kwong ASK Chan CW, Tsui WWS, Ngai HY, Chu DWS, Lee PWY, Chiu MC, Leung GM, Peiris JSM. Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households[J]. New Engl J Med 2010; 363: 2175-84.
Vijaykrishna D, Poon LLM, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GLD, Peiris JSM*, Guan Y*. Reassortment of pandemic H1N1/2009 influenza A virus in swine[J]. Science 2010; 328: 1529
Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JSM, Guan Y, Rambaut A. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic[J]. Nature. 2009;459:1122-5.
Nicholls JM, Chan MC, Chan WY, Wong HK, Cheung CY, Kwong DL, Wong MP, Chui WH, Poon LL, Tsao SW, Guan Y, Peiris JSM*. Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract[J]. Nat Med. 2007; 13: 147-9.
Li KS, Guan Y, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie AT, Chaisingh A, Auewarakul P, Long HT, Hanh NT, Webby RJ, Poon LL, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JSM. Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia[J]. Nature. 2004; 430:209-13.
Arunachalam PS, Wimmers F, Mok CKP, Perera RAPM, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tak-Yin Tsang O, Wagh D, Coller J, Pellegrini KL, Kazmin D, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, Paine McCullough M, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B. Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans[J]. Science. 2020;369: 1210-1220.
Hachim A, Kavian N, Cohen CA, Chin AWH, Chu DKW, Mok CKP, Tsang OTY, Yeung YC, Perera RAPM, Poon LLM, Peiris JSM, Valkenburg SA. ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection[J]. Nat Immunol. 2020; 21:1293-1301.
Mok CKP, Zhu A, Zhao J, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Alshukairi AN, Baharoon SA, Wang W, Tan W, Liang W, Oladipo JO, Perera RAPM, Kuranga SA, Peiris M*, Zhao J. T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study[J]. Lancet Infect Dis. 2021; 21:385-395.
Zhou Z, Hui KPY, So RTY, Lv H, Perera RAPM, Chu DKW, Gelaye E, Oyas H, Njagi O, Abayneh T, Kuria W, Walelign E, Wanglia R, El Masry I, Von Dobschuetz S, Kalpravidh W, Chevalier V, Miguel E, Fassi-Fihri O, Trarore A, Liang W, Wang Y, Nicholls JM, Zhao J, Chan MCW, Poon LLM, Mok CKP, Peiris M*. Phenotypic and genetic characterization of MERS coronaviruses from Africa to understand their zoonotic potential[J]. Proc Natl Acad Sci USA. 2021; 118: e2103984118.
裴伟士担任学术期刊《刺针感染性疾病》（Lancet Infectious Diseases）及《PLoS Medicine》编辑委员会委员。
“裴伟士发现了冠状病毒（SARS-CoV-1）为导致2003年全球重症急性呼吸综合征（SARS）病原，以及由动物到人的传染链，为人类应对MERS和COVID-19冠状病毒引起的传染病产生了重大影响”。（2021未来科学大奖生命科学奖颁奖词）
裴伟士在深入了解亚洲各地新发传染病，尤其是人畜流感及严重急性呼吸系统综合症（SARS）的爆发源头、疫情防控措施和策略等方面做出了重大贡献。（约翰‧狄克斯加拿大盖尔德纳全球卫生奖评）