更新时间：2023-01-04 23:49
曾任兰州大学附属一院住院医师,主治医师;美国北卡罗来纳大学 (University of North Carolina at Chapel Hill) 博士后，研究助理教授; 美国迈阿密大学 (University of Miami) 终身轨助理教授，副教授。
主要从事细胞增殖和分化与疾病,及基因工程小鼠的的研究工作。
共发表SCI期刊收录论文43篇，累计影响因子255分，第一作者发表论文最高影响因子25.3分。通讯作者发表论文最高影响因子9.3分。
代表性科研项目
Representative Grants and Contracts completed in USA (4 out of 17, Total $2,836,798):
1. Title: BRCA1 controls mammary stem/progenitor differentiation and proliferation, epithelial-mesenchymal transition and tumorigenesis
PI: Pei XH
Agency: Breast Cancer Research Program (BCRP)
Type: Idea Award (W81XWH-10-1-0302)
Amount: $554,491
Period: 4/15/2010 – 5/14/2012
2. Title: Adult stem cell cycle control and tumorigenesis
PI: Pei XH
Agency: University of Miami, Startup Funding
Amount: $978,522
Period:11/1/2010 – 5/31/2013
3. Title: The Role of BRCA1 in Suppressing Epithelial-Mesenchymal Transition in Mammary Gland and Tumor Development
PI: Pei XH
Agency: Breast Cancer Research Program (BCRP)
Type: Idea Expansion Award (W81XWH1310282)
Amount: $537,779
Period:9/1/2013 – 8/31/2016
4. Title: Targeting BRCA1 deficient breast cancers
PI: Pei XH
Agency:Florida Department of Health (Bankhead Coley Cancer Research Grant Award - 7BC07)
Amount: $97,880
Period: 3/1/17 - 2/28/18
代表性成果
· Wang C, Bai F, Zhang LH, Scott A, Li E, Pei XH. (2018) Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression. Breast Cancer Research. 20(1);74:1-17.
· Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou, CM, Livingstone AS, Robbins DJ, Capobianco AJ, Pei XH. (2014) BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development. Cancer Research. 74(21):6161-6172.
· Bai F, Smith MD, Chan HL, Pei XH. (2013) Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation. Oncogene. 30;32(22): 2715-2725. Featured Article.
Commentary in Oncogene: BRCA1 mutations and luminal-basal transformation. Ng T, Irshad S, Stebbing J. 2013 May 30;32(22):2712-2714.
· Pei XH, Bai F, Li Z, Smith MD, Whitewolf G, Jin R, and Xiong Y. (2011) Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Research. 71, 2969-2977.
· Pei XH*, Bai F*, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y. (2009) CDK inhibitor p18INK4c is a downstream target of GATA3 and controls mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell, 15, 389-401. *equal contribution.