更新时间：2023-10-26 11:19
解亭，香港科技大学讲席教授、生命科学部主任。解亭博士自2021年初起调任香港科技大学生命科学系主任兼讲座教授。他在中国农业大学获得植物遗传与育种学士和硕士学位，在罗格斯大学获得分子生物学和生物化学博士学位。作为霍华德休斯医学研究所的博士后研究员，他在卡内基科学研究所进行了博士后培训。然后，他加入了Stowers医学研究所，担任研究员近 20 年。在加入香港科技大学之前，他是Stowers医学研究所的全职研究员，也是堪萨斯大学医学中心的教授。主要研究方向为干细胞生物学和组织再生。他是研究干细胞生态位及其控制自我更新的机制的领导者和先驱之一。
1996年 罗格斯大学 分子生物学与生物化学博士
1990年 中国农业大学 硕士
1987年 中国农业大学 学士
2021年 香港科技大学 生命科学部 讲席教授 主任
2000-2020 美国Stowers医学研究所 研究员
1996-1999 约翰霍普金斯大学 博士后
干细胞自我更新与分化
视网膜退行性疾病以及潜在疗法
Tu R, Duan B, Song X, Chen S, Scott A, Hall K, Blanck J, DeGraffenreid D, Li H, Perera A, Haug J, Xie T. Multiple niche compartments orchestrate stepwise germline stem cell progeny differentiation. Current Biology. 2021; 31(4): 827-839.
Pang J, Le L, Zhou Y, Tu R, Hou Q, Tsuchiya D, Thomas N, Wang Y, Yu Z, Alexander R, Thexton M, Lewis B, Corbin T, Durnin M, Li H, Ashery-Padan R, Yan D, Xie T. Notch signaling controls ciliary body morphogenesis and secretion by directly regulating Nectin expression. Cell Reports. 2021; 34(2): 108603.
Tu R, Duan B, Song X, Xie T. Glypican Dlp-mediated Hedgehog and Wnt signaling interdependence is crucial in the niche for germline stem cell progeny differentiation. Science Advances. 2020; aaz0480.
Zuo F, Tu R, Duan B, Yang Z, Ping Z, Song X, Chen S, Price A, Li H, Scott A, Perera A, Li S, Xie T. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proc Natl Acad Sci U S A. 2020; 117(7): 3603-3609.
Mao Y, Tu R, Huang Y, Mao D, Yang Z, Lau PK, Ni J, Guo Y, Xie T. The exocyst functions in niche cells to promote germline stem cell progeny differentiation by directly controlling EGFR membrane trafficking. Development. 2019;146(13): dev174615.
Ma X, Zhu X, Han Y, Story B, Do T, Song X, Wang S, Zhang Y, Blanchette M, Gogol M, Malanowski K, Peak A, Anoja P, Xie T. Aubergine controls germline stem cell self-renewal and progeny differentiation via distinct mechanisms. Developmental Cell 2017; 41(2):157-169.
Ma X, Han Y, Song X, Do T, Yang Z, Ni J, Xie T. DNA damage-induced CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. Development. 2016; 143(23):4312-4323.
Lu T, Wang S, Gao Y, Mao Y, Yang Z, Liu L, Song X, Ni J, Xie T. COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila Ovary. Development. 2015; 142(24):4242-52.
Fu Z, Geng C, Wang H, Yang Z, Weng C, Li H, Deng L, Liu L, Liu N, Ni J, Xie T. Twin promotes the maintenance and differentiation of germline stem cell lineage through modulating multiple pathways. Cell Reports. 2015; 13(7):1366-79.
Wang S, Gao Y, Song X, Ma X, Zhu X, Mao Y, Yang Z, Ni J, Li H, Malanowski KE, Anoja P, Park J, Haug J and Xie T. Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. eLife. 2015; 4:e08174.
Ouyang J, Yu W, Liu J, Zhang N, Florens L, Chen J, Liu H, Washburn M, Pei D, Xie T. Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state. J Biol Chem. 2015; 290(37):22782-94.
Pan L, Wang S, Lu T, Weng C, Song X, Park JK, Sun J, Yang ZH, Yu J, Tang H, McKearin DM, Chamovitz DA, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014; 514(7521):233-6.
Chen S, Li H, Gaudenz K, Paulson A, Guo F, Trimble R, Peak A, Seidel C, Deng C, Furuta Y, Xie T. Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis. Cell Res. 2013; 23(2):254-73.
Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T. Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye. Proc Natl Acad Sci U S A. 2013; 110: 8966-71.
Li T, Lewallen M, Chen S, Yu W, Zhang N, Xie T. Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res. 2013; 23(6):788-802.
Kirilly D, Wang S, Xie T. Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011; 138:5087-5097.
Wang X, Pan L, Wang S, Zhou J, McDowell W, Park J, Haug J, Staehling K, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. PLoS Genet. 2011; 7:e1002426.
Chen S, Kaneko S, Ma X, Chen X, Ip YT, Xu L, Xie T. Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion. Proc Natl Acad Sci U S A. 2010; 107:19939-19944.
Shen R, Weng C, Yu J, Xie T. eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc Natl Acad Sci U S A. 2009; 106:11623-11628.
Shen R, Xie T. Stem cell self-renewal versus differentiation: tumor suppressor Mei-P26 and miRNAs control the balance. Cell Res. 2008; 18:713-715.
Jin Z, Kirilly D, Weng C, Kawase E, Smith S, Schwartz J, Xie T. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2008; 2:39-49.
Song X, Call GB, Kirilly D, Xie T. Notch signaling controls germline stem cell niche formation in the Drosophila ovary. Development. 2007; 134:1071-1080.
Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary. Cell Stem Cell. 2007; 1:458-469.
Jin Z, Xie T. Dcr-1 maintains Drosophila ovarian stem cells. Curr Biol. 2007; 17:539-544.
Xi R, Xie T. Stem cell self-renewal controlled by chromatin remodeling factors. Science. 2005; 310:1487-1489.
Xi R, Doan C, Liu D, Xie T. Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway. Development. 2005; 132:5365-5374.
Kirilly D, Spana EP, Perrimon N, Padgett RW, Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell. 2005; 9:651-662.
Song X, Wong MD, Kawase E, Xi R, Ding BC, McCarthy JJ, Xie T. Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development. 2004; 131:1353-1364.
Kawase E, Wong MD, Ding BC, Xie T. Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis. Development. 2004; 131:1365-1375.
Zhu CH, Xie T. Clonal expansion of ovarian germline stem cells during niche formation in Drosophila. Development. 2003; 130:2579-2588.
Song X, Xie T. Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development. 2003; 130:3259-3268.
Song X, Zhu CH, Doan C, Xie T. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science. 2002; 296:1855-1857.
Song X, Xie T. DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary. Proc Natl Acad Sci USA. 2002; 99:14813-14818.
Xie T, Spradling AC. A niche maintaining germ line stem cells in the Drosophila Ovary. Science. 2000; 290:328-330.
Xie T, Spradling AC. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell. 1998; 94:251-260.
Xie T, Finelli AL, Padgett RW. The Drosophila saxophone gene: a serine-threonine kinase receptor of TGF-b superfamily. Science. 1994; 263:1756-1759.
解亭博士主要研究方向为干细胞生物学和组织再生。他是研究干细胞生态位及其控制自我更新的机制的领导者和先驱之一。解亭博士是最早通过实验证明存在干细胞生态位的人之一。他的实验室还提出并证明了控制干细胞谱系规范的分化生态位的存在；以及阐明了这两个生态位如何协同工作来控制干细胞发育，从而控制组织再生。最近，他将研究兴趣扩大到视网膜退行性疾病和开发新的治疗策略。迄今为止，他已在知名期刊上发表了 70 多篇文章，包括括Nature, Science 和 Cell。他于 2003 年获得哈德逊奖，并一直担任青光眼基金会科学顾问委员会和Cell Research , Development等八种科学期刊的编委。