为了尽到自己身为一个白血球的的神圣责任，为了挽救富兰克的生命，奥兹和德雷克斯决定先放下对彼此的成见，携手并肩共抗外敌。他们两个人同生物钟比赛争分夺秒：避开粘液泥浆、清理毒素以及所有你想象不到的各种工作。这是份很脏的工作，但是这些抗体必须去做。因为每个身体都需要英雄。与此同时，弗兰克因为身体不适去看医生，他的医生也正竭力想找出到底是什么导致了弗兰克的病症。

* 鲍比·法拉利 Bobby Farrelly

*彼得·法拉利Peter Farrelly

* Marc Hyman .....(written by)

*克里斯·洛克Chris Rock .....Osmosis Jones (voice)

*劳伦斯·菲什伯恩Laurence Fishburne .....Thrax (voice)

* 大卫·海德·皮尔斯 David Hyde Pierce .....Drix (voice)

* Brandy Norwood .....Leah (voice)

*威廉·夏特纳William Shatner .....Mayor Phlegmming (voice)

*朗·霍华德Ron Howard .....Tom Colonic (voice)

* 基德·洛克 Kid Rock .....Kidney Rock (voice)

* Kenny Olson .....Kidney Rock (voice)

* Jason Krause .....Kidney Rock (voice)

* Joe C. .....Kidney Rock (voice)

* Stefanie Eulinberg .....Kidney Rock (voice)

* Jimmie Bones .....Kidney Rock (voice)

* Uncle Kracker .....Kidney Rock (voice)

* Jonathan Adams .....Additional Character Voice (voice)

* Carlos Alazraqui .....Additional Character Voice (voice)

* Keith Anthony .....Additional Character Voice (voice)

* Eddie Barth .....Additional Character Voice (voice)

* Sally Ann Brooks .....Additional Character Voice (voice)

* Rodger Bumpass .....Additional Character Voice (voice)

* Michael Carven .....Additional Character Voice (voice)

* Paul Christie .....Additional Character Voice (voice)

* Janis Dardaris .....Additional Character Voice (voice)

* Wendy Dillon .....Additional Character Voice (voice)

* Antonio Fargas .....Additional Character Voice (voice)

* Eddie Frierson .....Additional Character Voice (voice)

* Donald Fullilove .....Additional Character Voice (voice) (as Don Fullilove)

* Jackie Gonneau .....Additional Character Voice (voice)

* Shannon Gregory .....Additional Character Voice (voice)

* Rif Hutton .....Additional Character Voice (voice)

* Richard Steven Horvitz .....Additional Character Voice (voice) (as Richard Horvitz)

* Art Kimbro .....Additional Character Voice (voice)

* Joyce Kurtz .....Additional Character Voice (voice)

* Anne Lockhart .....Additional Character Voice (voice)

* Sherry Lynn .....Additional Character Voice (voice)

* Danny Mann .....Additional Character Voice (voice)

* Mickie McGowan .....Additional Character Voice (voice)

* 'Stuttering' John Melendez .....Additional Character Voice (voice)

* Héctor Mercado .....Additional Character Voice (voice)

* Paul Pape .....Additional Character Voice (voice)

* Marilyn Pasekoff .....Additional Character Voice (voice)

* Chris Phillips .....Additional Character Voice (voice)

* Lynne Redding .....Additional Character Voice (voice)

* Al Rodrigo .....Additional Character Voice (voice)

* Herschel Sparber .....Additional Character Voice (voice)

* Doug Stone .....Additional Character Voice (voice)

* Steve Susskind .....Additional Character Voice (voice)

* Keri Tombazian .....Additional Character Voice (voice)

* Paul Tuerpe .....Additional Character Voice (voice)

* Robert Wisdom .....Additional Character Voice (voice)

*比尔·默瑞Bill Murray .....Frank Detomello

*莫莉·香侬Molly Shannon .....Mrs. Boyd

* 克里斯·艾略特 Chris Elliott .....Bob

* Elena Franklin .....Shane Detomello

* Danny Murphy .....Zookeeper Superintendent

* Jack McCullough .....Zookeeper

* Kathy Wege .....Mrs. Claris, Volcano Lady

* Will Dunn .....Oyster Boy

* Jackie Flynn .....School Janitor

* Kelsey Jordan .....Bus Girl #1

* Anna Byers .....Bus Girl #2

* Jesse Peter .....Laughing Boy

* John-Eliot Jordan .....Pea Soup Manager (as John Jordan)

* Nancy Byers .....Pea Soup Supervisor

* Kevin J. Flynn .....Docky's Clamshack Waiter (as Kevin Flynn)

* Sean Gildea .....Dreamy Photographer

* Kathryn Frick .....Nurse #1

* Nicki Tyler Flynn .....Nurse #2 (as Nikki Tyler-Flynn)

* Elizabeth Jordan .....Nurse #3

* Zen Gesner .....Emergency Room Doctor #1

* Marc Hyman .....Emergency Room Doctor #2

* Zak Penn .....Emergency Room Doctor #3

* Bob O'Brien .....The Zoo Visitors & Staff

* Tom Beachene .....The Zoo Visitors & Staff

* Diane Conrad .....The Zoo Visitors & Staff

* Judy Conrad .....The Zoo Visitors & Staff

* Bob Fennessy .....The Zoo Visitors & Staff

* John Britten .....The Zoo Visitors & Staff

* Katie Britten .....The Zoo Visitors & Staff

* Marlene Malone .....The Zoo Visitors & Staff

* Grady O'Connor .....The Zoo Visitors & Staff

* Barbara O'Connor .....The Zoo Visitors & Staff

* Jacqueline Wentzell .....The Zoo Visitors & Staff

* Morgan Wentzell .....The Zoo Visitors & Staff

* Jamie Heres .....The Zoo Visitors & Staff

* Jimmy Heres .....The Zoo Visitors & Staff

* Thomas Jordan .....The Zoo Visitors & Staff

* Ruth Meyer .....The Zoo Visitors & Staff

* Mandy Marsh .....The Zoo Visitors & Staff

* Tommy Barbieri .....The Zoo Visitors & Staff

* Allison Barbieri .....The Zoo Visitors & Staff

* Erica Johnson .....The Zoo Visitors & Staff

* Sydney J. Bartholomew Jr. .....The Zoo Visitors & Staff (as Sidney Jackson Bartholomew Jr.)

* Bill Beauchene .....The Science Fair Contestants & Families

* Buzz Dunn .....The Science Fair Contestants & Families

* Laura Dunn .....The Science Fair Contestants & Families

* Krista-Jean Forand .....The Science Fair Contestants & Families

* Kena Flynn .....The Science Fair Contestants & Families

* Christina Kacmar .....The Science Fair Contestants & Families

* Diana O'Donnell .....The Science Fair Contestants & Families

* Dick Silva .....The Science Fair Contestants & Families

* Allison Kacmar .....The Science Fair Contestants & Families

* Nicole Brathwaite .....The Volcano Gal

* Emily O'Day .....The Volcano Gal

* Brianna Cabral .....The Volcano Gal

* Catherine Dunphy .....The Volcano Gal

* Chandler Vuilleumier .....The Volcano Gal

* Bill Wade .....Pea Soup Staff

* Bo Cleary .....Pea Soup Staff

* Bruce McIntyre .....Pea Soup Staff

* Colleen O'Donnell .....Docky's Clamshack

* Maryjane Foy .....Docky's Clamshack

* Jo Ann Nicewicz .....Docky's Clamshack

* Jillian Nicewicz .....Docky's Clamshack

* Docky .....The Bikini Gang

* Heidi Hetzel .....The Bikini Gang

* Patricia Guiggey .....The Bikini Gang

* Rachael Kasner .....The Bikini Gang

* George Kouri .....The Bikini Gang

* Joe Murphy .....The Bikini Gang

* Dick Rubin .....The Bikini Gang

* Amy Suhay .....The Bikini Gang

* Brian Mone .....Police Officer

* Sean Fitzgerald .....Police Officer

* Beth Jordan .....The Emergency Room Nurse

* Mattie Ostiguy .....The Emergency Room Nurse

* Grace Costa .....The Emergency Room Nurse

* Maura O'Brien .....The Emergency Room Nurse

* Kathy Farrelly .....Nurse (uncredited)

* Shawn Fogarty .....Father at science fair (uncredited)

* Camden Munson .....(uncredited)

*乔·西尔沃Joel Silver .....Police Chief (voice) (uncredited)

* Ben Stein .....Doc (uncredited)

* Ben Urann .....Student (uncredited)

* Cortney Urichuck .....Student (uncredited)

* Megan Urichuck .....Student (uncredited)

* Jillian Wheeler .....Student (uncredited)

* Billy Frank .....producer: theatrical trailer

* Aaron Parry .....associate producer

* Zak Penn .....producer

* Bradley Thomas .....producer

* John Walker .....associate producer

国家/地区上映/发行日期

美国

USA

2001年8月7日 ..... (premiere)

美国

USA

2001年8月10日

西班牙

Spain

2001年9月14日

挪威

Norway

2001年9月19日

新加坡

Singapore

2001年9月20日

马来西亚

Malaysia

2001年9月20日

荷兰

Netherlands

2001年9月22日 ..... (Nederlands Film Festival)

荷兰

Netherlands

2001年10月11日

菲律宾

Philippines

2001年10月11日

冰岛

Iceland

2001年10月19日

瑞典

Sweden

2001年10月26日

土耳其

Turkey

2001年10月26日

英国

UK

2001年11月2日

捷克

Czech Republic

2001年12月6日

比利时

Belgium

2001年12月19日

法国

France

2001年12月19日

立陶宛

Lithuania

2002年1月18日

科威特

Kuwait

2002年2月20日

阿根廷

Argentina

2002年4月17日 ..... (video premiere)

德国

Germany

2002年4月18日 ..... (video premiere)

俄罗斯

Russia

2002年6月 ..... (DVD premiere)

澳大利亚

Australia

2002年8月1日

日本

Japan

2002年12月6日 ..... (video premiere)

插曲——歌曲：Key To My Heart歌手Craig David

其中影片65分59秒，奥兹及德雷克斯离开弗兰克体内时插曲

歌曲：Key To My Heart歌手Craig David

歌词

法莱利兄弟这次终于把他们的“魔掌”伸到了动画领域，在这部真人结合动画的影片中，兄弟俩著名的“体液笑料”可谓是发挥得出神入化，打喷嚏放屁等等傻瓜幽默层出不穷，看完后人们或许会奇怪何以这两个人会对这种恶心题材如此热衷？这部片子最初拿到了一个PG-13的评级，影评人担心如果有家长带孩子去收看这部《终极细胞战》时会产生某种不良影响，华纳公司权衡利弊，为了占领暑假这个孩子们最为活跃的时期，决定将片子中太粗俗过分的地方做出相应删改，这才最终得到了PG级。

在1999年推出了广受好评的长篇动画电影《钢铁巨人》之后，华纳公司十分看好动画市场，他们想到了一个很能出彩的创意，将人体内的细胞赋予生命，让他们有思想有性格，成为单独的个体，不过看看剧情，眼明的观众恐怕会一下子联想到N多电影的情节，《人体旅行》、《致命武器》、《傀儡人生》、《谁陷害了兔子罗杰》乃至最近的《15分钟》，把这些熟悉的情节放到卡通形象上到底是个什么味道，只有让观众自己去体味一番了。华纳自己倒是显得相当有信心，片子还没公映，华纳就宣布买断13个该片的电视剧单元，只等电影上映完再到电视上捞一把。

本片的制作开始时，有传言说好莱坞金童威尔·史密斯将为片中的动画男主角奥兹配音，但是在正式公布名单的时候，这个名字换成了克里斯·洛克，不过试看过样片的观众都对洛克的表现很满意，认为他的声音更有跳跃感，更活泼，同角色的性格十分配合。而给反面人物——病毒斯瑞克司配音是的黑人男星劳伦斯·费舍伯恩，大家对他在《黑客帝国》里饰演的黑客领袖一定印象犹新，他的声音浑厚深沉而内敛，这次费舍伯恩将用声音扮演一个阴险狡诈的反角，想来也很值得影迷们期待。