更新时间：2023-10-24 11:07
魏海明，男，安徽人，博士，中国科学技术大学教授、博士生导师。现为中国科学技术大学生命科学实验中心常务副主任，中国科学技术大学生命学院实验动物中心主任，中国免疫学会英文会刊Cellular & Molecular Immunology编辑部主任。中国免疫学会终身会员、理事，中国免疫学会青年学术委员会委员，中国抗癌协会肿瘤生物治疗专业委员会委员，安徽省免疫学会理事长。
1996.7－2000.10山东省医学科学院基础医学研究所助理研究员；
2000.11－2001.8山东省医学科学院基础医学研究所副研究员；
2001.9－2005.12中国科学技术大学生命学院副教授；
2005.12－至今中国科学技术大学生命学院教授;
1993.8-1996.7山东省医学科学院硕士研究生；
2000.8-2003.7山东大学博士研究生
1、天然免疫识别及其分子机制
2、肿瘤免疫学与肿瘤生物治疗
3、天然免疫系统与重大疾病
1) Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors. - Cancer Sci. - 200903 - 2009 Mar;100(3):529-36.
2) Diagnostic utility of LunX mRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer. - BMC Cancer - 200805 - 2008 May 31;8:156.
3) Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus - Journal of Immunology - 2011 - 186(6):3421-3431
4) IFN-r induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice - Journal of Autoimmunity - 2012 - 38(1):20-28
5) CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells - Immunology - 2011 - 133(3):350-359
6) IGF-1 promotes the development and cytotoxic activity of human NK cells. - Nat Commun. - 2013 - 4:1479
7) Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. - Proc Natl Acad Sci U S A. - 2013 - 2013 Jan 15;110(3):E231-40
8) TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. - PLoS Pathog. - 2012 - 2012;8(3):e1002594
9) Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice - BBRC - 2007 - 2007 Dec;28;364(4):978-84
10) Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBAxDBA/2 mice - J Reprod Immunol. - 200706 - 2007;74(1-2):61-7
11) Involvement of Human natural killer (NK) cells in asthma pathogenesis: NK2 cells in type-two cytokine predominance. - J Allergy Clin Immunol. - 200504 - 2005;115(4): 841-7
12) Tumor-induced suppression of interferon production and enhancement of interleukin-10 production by natural killer (NK) cells: paralleled to CD4+ T cells. - Molecular Immunology - 200505 - 2005;42(9):1023-31
13) NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice - PNAS - 200705 - 2007;104(18):7512-5
14) Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. - Hepatology. - 200802 - 2008;47(2):648-58.
15) IFN-producing Killer Dendritic Cells Contribute to the Inhibitory Effect of Poly I:C on the Progression of Murine Melanoma. - J Immunother. - 200807 - 2008;31(6):555-62.
16) Hepatocytes proteomic alteration and seroproteome analysis of HBV-transgenic mice. - Proteomics. - 200901 - 2009;9(1):87-105
17) Toll-like receptor 3 agonist enhances IFN-rand TNF-a production by murine uNK cells - Int Immunopharmacol - 200705 - 2007 May;7(5):588-96
18) Synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, inhibit the function of human NK cells: implication in therapy of autoimmune liver injury. - Peptides - 200503 - 2005; 26(3): 405-12.
19) Recognition of Double-Stranded RNA by TLR3 induces Severe Small Intestinal Injury in Mice. - J Immunol. - 200704 - 2007;178(7):4548-56
20) Application of optical tweezers in the research of molecular interaction between lymphocyte function associated antigen-1 and its monoclonal antibody. - Cell Mol Immunol. - 200706 - 2007;4(3):221-5.
“重大新药创制”科技重大专项1项，国家863课题1项，国家973课题1项，国家自然科学基金重点项目1项。
2002年以来为首承担参加了9项科研项目，其中国家863课题2项，国家973课题2项，国家自然科学基金项目重点项目1项、面上项目2项，国家新药创制重大专项1项，国家杰出青年科学基金B类1项(国内负责人)。
2020年安徽省优秀共产党员
2010年获中华医学科技一等奖
2008年获国家自然科学二等奖
2007年获中华医学科技一等奖
2020年9月8日，被评为全国抗击新冠肺炎疫情先进个人。
2022年2月，获第二十二届“吴阶平—保罗·杨森医学药学奖”。
2022年2月，魏海明担任负责人的中国科学技术大学 临床免疫学教师团队被教育部评选为第二批全国高校黄大年式教师团队。