更新时间：2023-12-29 11:07
2006-09--2011-06 中国科学院上海药物研究所 理学博士
2002-09--2006-06 中国药科大学、南京大学 理学学士
2011-07, 中国科学院上海药物研究所, 助理研究员、副研究员、研究员
2006-09~2011-06,中国科学院上海药物研究所, 理学博士
2002-09~2006-06,中国药科大学、南京大学, 理学学士
100706-药理学
抗肿瘤药物药理研究，表观遗传研究
（ 1 ） 乙酰肝素酶动态调控肿瘤微环境肝癌恶性转化中的分子机制, 负责人, 国家任务, 2014-01--2016-12
（ 2 ） 靶向ECM抑制剂JG6的个性化特征及标志物研究, 负责人, 中国科学院计划, 2015-09--2015-12
（ 3 ） Menin-MLL1 PPI抑制剂先导化合物发现研究, 负责人, 中国科学院计划, 2016-01--2017-12
（ 4 ） 精氨酸甲基转移酶PRMT5肿瘤个性化特征与抑制剂研发, 负责人, 中国科学院计划, 2019-01--2020-12
（ 5 ） 甲基化相关复合物结构功能技术, 负责人, 国家任务, 2018-01--2020-12
（ 6 ） EZH2抑制剂候选药物发现研究, 负责人, 国家任务, 2018-01--2020-12
（ 7 ） “个性化药物--基于疾病分子分型的普惠新药研发”： 精氨酸甲基化酶CARM1靶点确证与选择性抑制剂研发, 参与, 中国科学院计划, 2019-01--2020-12
（ 8 ） 消化系统恶性肿瘤诊疗新技术研发及精准干预应用研究, 参与, 地方任务, 2019-01--2023-12
1.Xun Huang#, Juan Yan#, Min Zhang#, Yafang Wang#, Yi Chen, Xuhong Fu, Rongrui Wei, Xingling Zheng, Zhiwei Liu, Xiong Zhang, Hong Yang, Binbin Hao, Yanyan Shen, Yi Su, Xiaoji Cong, Min Huang, Minjia Tan*, Jian Ding*, Meiyu Geng*. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-aberrant Solid Tumors. Cell, 2018;175:186-199.
2.Xiaoyang Dai#, Juan Yan#, Xuhong Fu, Qiuming Pan, Danni Sun, Yuan Xu, Jiang Wang, Litong Nie, Linjiang Tong, Aijun Shen, Mingyue Zheng, Min Huang, Minjia Tan, Hong Liu, Xun Huang*, Jian Ding*, Meiyu Geng*. Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase. Clin Cancer Res, 2017;23(20):6267-6278.
3.Xiong Zhang#, Xingling Zheng#, Hong Yang, Juan Yan, Xuhong Fu, Rongrui Wei, Xiaowei Xu, Zhuqing Zhang, Aisong Yu, Kaixin Zhou, Jian Ding*, Meiyu Geng*, Xun Huang*. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett, 2018;431:150-160.
4.Danni Sun#, Hongchun Liu#, Xiaoyang Dai, Xingling Zheng, Juan Yan, Rongrui Wei, Xuhong Fu, Min Huang, Aijun Shen, Xun Huang*, Jian Ding*, Meiyu Geng*. Aspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition. Cancer Lett, 2017;406:105-115.
5.Zuhao Guo#, Zhuqing Zhang#, Hong Yang, Danyan Cao, Xiaowei Xu, Xingling Zheng, Danqi Chen, Qi Wang, Yanlian Li, Jian Li, Zhiyan Du, Xin Wang, Lin Chen, Jian Ding, Jingkang Shen, Meiyu Geng*, Xun Huang*, Bing Xiong*. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia. J Med Chem, 2019;62(11):5414-5433.
6.Ruiqi Liu# , Zhuqing Zhang#, Hong Yang, Kaixin Zhou, Meiyu Geng, Weicheng Zhou*, Mingming Zhang*, Xun Huang*, Yingxia Li*. Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors. Eur J Med Chem, 2019;180:171-190.
7.Lidan Sun#, Xun Huang#, Jing Han, Xingguang Cai, Yuxuan Dai, Yingying Chu, Chuandong Wang, Wenlong Huang*, Hai Qian*. Site-specific fatty chain-modified exenatide analogs with balanced glucoregulatory activity and prolonged in vivo activity. Biochem Pharmacol, 2016;110-111:80-91.
8.Xun Huang#, Danni Sun#, Qiuming Pan, Weiwei Wen, Yi Chen, Xianliang Xin, Min Huang, Jian Ding* and Meiyu Geng*. JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin. Oncotarget, 2014;5(11):3568-78.
9.Xun Huang#, Qiuming Pan#, Danni Sun, Wei Chen, Aijun Shen, Min Huang, Jian Ding*, Meiyu Geng*. O-GlcNAcylation of Cofilin Promotes Breast Cancer Cell Invasion. J Biol Chem, 2013;288(51):36418-25.
10.Shuai Wang#, Xun Huang#, Danni Sun, Xianliang Xin, Qiuming Pan, Shuying Peng, Zhongjie Liang, Cheng Luo, Yiming Yang, Hualiang Jiang, Min Huang, Wengang Chai, Jian Ding*, Meiyu Geng*. Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling. PLoS ONE, 2012;7(5): e37427.